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教授/青年教授/青年研究员

冯杰

职　　务：

职　　称：教授

电子邮箱：jfeng@lzu.edu.cn

科研方向：病原微生物耐药及持留机制研究；抗菌药物发现及作用机制研究；基因组系统进化

冯杰， 2007年毕业于华中科技大学同济医学院，同年获得武汉大学生物科学双学士学位。2012年获武汉大学微生物学博士学位。2013年赴美国约翰霍普金斯大学布隆伯格公共卫生学院(Bloomberg School of Public Health, Johns Hopkins University)从事博士后研究。并于2019年加入兰州大学基础医学院。长期从事病原微生物学基础研究，开发了新的高通量微生物活力检测方法;对伯氏疏螺旋体、巴通体、结核分枝杆菌等人兽共患病原体的持留和耐药机理进行了研究;并开展了高通量的药物筛选，发现了一批新的抗持留菌药物和药物前体。以第一作者或通讯作者发表SCI论文20余篇。系列研究成果被权威综述期刊Nature Reviews Microbiology，Clinical Microbiology Reviews, Chemical Reviews, FEMS Microbiology Reviews引用。担任SCI二区期刊Frontiers in Microbiology“感染性疾病”方向客座编辑、“抗生素、耐药和化疗”方向审稿编辑。主持了国家自然科学基金、甘肃省科技专员专项、甘肃省联合基金重点项目等课题。

1.病原微生物耐药及持留机制的深入研究。本实验室在建立持留菌模型的基础上利用多组学、突变株筛选等方法鉴定与持留菌形成相关的基因和机制。了解不同微生物耐药和持留的机制，从而寻找相关的药物靶点。

2.新型抗菌药物的筛选。利用前期建立的高效、高通量、高灵敏度微生物活性检测方法，针对耐药菌、持留菌等多种病原生物，筛选并发现具有高效、低副作用、特异性好的药物、天然产物或先导化合物。

3.伯氏疏螺旋体、巴通体等人兽共患病原的致病机制研究。

4.微生物组学及微生物系统进化研究。通过生物信息学和多种培养技术，研究人体微生物组与健康疾病的关系。多种病毒、原核生物、真核生物全基因组系统进化的分析研究。

  1. 第一作者或通讯作者发表的SCI论文：
  1. Wang, T., Y. Wang, S. Wang, Y. Che, T. Che, J. Feng* and T. Li* (2026). "Fungal co-cultivation reshapes salt stress adaptation in the cyanobacterium Synechococcus elongatus PCC 7942." Algal Research 96: 104740.
  2. Gou Y, Liu D, Xin Y, Wang T, Li J, Xi Y, Zheng X, Che T, Zhang Y, Li T*, Feng J* (2024). Viable but nonculturable state in the zoonotic pathogen Bartonella henselae induced by low-grade fever temperature and antibiotic treatment. Front Cell Infect Mi, 14: 1486426.
  3. T. Li, Y. Xin, D. Liu, J. Sun, J. Li, Y. Zhang* and J. Feng* (2023). "High-throughput Drug Screening on Borrelia garinii and Borrelia afzelii Identified Hypocrellin A as an Active Drug Candidate Against Borrelia Species." Infect Microbe Dis 5, 83-92；
  4. J. Feng*, T. Lin, A. D. Mihalca, Q. Niu and M. C. Oosthuizen (2023). "Editorial: Coinfections of Lyme disease and other tick-borne diseases." Front Microbiol 14: 1140545；
  5. Jin, X., Y. Gou, Y. Xin, J. Li, J. Sun, T. Li* and J. Feng* (2023). "Advancements in understanding the molecular and immune mechanisms of Bartonella pathogenicity." Front Microbiol 14: 1196700.
  6. J. Feng, J. Li, D. Liu, Y. Xin, J. Sun, W.-B. Yin and T. Li* (2023). "Generation and comprehensive analysis of Synechococcus elongatus–Aspergillus nidulans co-culture system for polyketide production." Biotechnol for Biof and Biop 16(1): 32；
  7. Q. Zhang, T. Li, J. Niu, J. Xiao, M. Zhang, R. Zhang, D. Chen, Y. Shi, X. Zhang, X. Hu, B. Yu, J. Feng* and Q. Fang* (2022). "Inhibitory effects of antibiotic-induced gut microbiota depletion on acute itch behavior in mice." Brain Res Bull 190: 50-61；
  8. T. Li, D. Liu, Y. Yang, J. Guo, Y. Feng, X. Zhang, S. Cheng and J. Feng* (2020). "Phylogenetic supertree reveals detailed evolution of SARS-CoV-2." Sci Rep 10(1): 22366；
  9. J. Feng, J. Leone, S. Schweig, Y. Zhang* (2020). Evaluation of natural and botanical medicines for activity against growing and non-growing forms of B. burgdorferi. Front Med 7, 6；
  10. J. Feng, T. Li, R. Yee, Y. Yuan, C. Bai, M. Cai, W. Shi, M. Embers, C. Brayton, H. Saeki, K. Gabrielson and Y. Zhang* (2019). Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure. Discov Med 27(148): 125-138；
  11. J. Feng, R. Yee, S. Zhang, L. Tian, W. Shi, W.-H. Zhang, and Y. Zhang*, (2018). A Rapid Growth-Independent Antibiotic Resistance Detection Test by SYBR Green/Propidium Iodide Viability Assay. Front Med 5, 127；
  12. J. Feng, W. Shi, J. Miklossy, G. M. Tauxe, C. J. McMeniman and Y. Zhang* (2018). "Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi." Antibiotics 7(4).
  13. J. Feng, S. Zhang, W. Shi, N. Zubcevik, J. Miklossy, and Y. Zhang* (2017). Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Front Med 4: p. 169；
  14. J. Feng, S. Zhang, W. Shi, and Y. Zhang* (2017). Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro. Antibiotics 6:10.
  15. J. Feng, S. Zhang, W. Shi and Y. Zhang* (2016). "Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/Doxycycline/Cefuroxime without Pulse Dosing." Front Microbiol 7:1744.
  16. J. Feng, W. Shi, S. Zhang, D. Sullivan, P. G. Auwaerter and Y. Zhang* (2016). "A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library." Front Microbiol 7: 743
  17. J. Feng, M. Weitner, W. Shi, S. Zhang, and Y. Zhang* (2016). "Eradication of Biofilm-like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime" Front Microbiol 7:62.
  18. J. Feng, W. Shi, S. Zhang and Y. Zhang* (2015). "Persister mechanisms in Borrelia burgdorferi: implications for improved intervention." Emerg Microbes Infect 4(8): e51.
  19. J. Feng, W. Shi, S. Zhang and Y. Zhang* (2015). "Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection." Emerg Microbes Infect 4: e31.
  20. J. Feng, P. G. Auwaerter and Y. Zhang* (2015). "Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline." PLoS One 10(3): e0117207.
  21. J. Feng, M. Weitner, W. Shi, S. Zhang, D. Sullivan and Y. Zhang* (2015) Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics 4: 397.
  22. J. Feng, T. Wang, W. Shi, S. Zhang, D. Sullivan, P. G. Auwaerter and Y. Zhang* (2014). "Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library." Emerg Microbes Infect 3: e49.
  23. J. Feng, T. Wang, S. Zhang, W. Shi and Y. Zhang* (2014). "An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi." PLoS One 9(11): e111809.
  24. J. Feng, J. Wang, Y. Zhang, X. Du, Z. Xu, Y. Wu, W. Tang, M. Li, B. Tang* and X. F. Tang* (2014). "Proteomic analysis of the secretome of haloarchaeon Natrinema sp. J7-2." J Proteome Res 13(3): 1248-1258.
  25. J. Feng, B. Liu, Z. Zhang, Y. Ren, Y. Li, F. Gan, Y. Huang, X. Chen, P. Shen, L. Wang, B. Tang and X. F. Tang* (2012). "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements." PLoS One 7(7): e41621.

 

  1. 国际会议邀请报告：
  1. Jie Feng; Phylogenetic Supertree of Virus, MATHEMATICS OF EVOLUTION-PHYLOGENETIC TREES AND NETWORKS, National University of Singapore, 2023-09-24至2023-09-28 (邀请大会报告)
  2. Jie Feng; 2nd Annual Lyme Disease in the Era of Precision Medicine conference, Icahn School of Medicine Mount Sinai in NY, New York, 2017-10-03至2017-10-04 (参加学术会议)
  3. Jie Feng; 3rd Annual Lyme Disease in the Era of Precision Medicine Conference, New York Academy of Medicine, 1216 5th Ave., New York, NY, 2018-10-02至2018-10-03 (参加学术会议)

 

 

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