多肽药物化学与药理学

主持科研项目：

1、国家自然科学基金青年基金(NSFC21502079)1项， 2016.01-2018.12。

2、中央高校基本科研业务费面上项目lzujbky-2015-163，2015.01-2016.06。

3、中央高校基本科研业务费面上项目lzujbky-2015-278，2015.07-2016.12。

近五年代表性论文：

1.  Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts， Bao, Guangjun; Song, Xinyi; Li, Yiping; He, Zeyuan; Zuo, Quan; E, Ruiyao; Yu, Tingli; Li, Kai; Xie, Junqiu*; Sun, Wangsheng*; Wang, Rui*；Nat. Commun.，2024，15（1），6909。（IF = 14.7）

2.    Cysteine-Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5-Substituted 1,2,3-Triazines，Zuo, Quan; Li, Yiping; Lai, Xuanliang; Bao, Guangjun; Chen, Lu; He, Zeyuan; Song, Xinyi; E, Ruiyao; Wang, Pengxin; Shi, Yuntao; Luo, Huixin; Sun, Wangsheng*; Wang, Rui*；Adv. Sci.，2024，11（21），2308491。（IF = 14.3）

3.    Intermolecular sulfur atom transfer cascade enabled late-stage introduction of sulfilimines into peptides， He, Zeyuan; Liu, Yuyang; Bao, Guangjun; Li, Yiping; Zhao, Xiufang; Zuo, Quan; Li, Kai; Sun, Wangsheng*; Wang, Rui；Chem. Sci.，2024，15, 17058-17063。（IF = 7.6）

4.    Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylation，Liu, Yuyang; Li, Guofeng; Ma, Wen; Bao, Guangjun; Li, Yiping; He, Zeyuan; Xu, Zhaoqing*; Wang, Rui*; Sun, Wangsheng*; Chem. Sci.，2024, 15(28)，11099-11107。（IF = 7.6）

5.    Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C-S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides，Bao, Guangjun; Wang, Peng; Li, Jingyue; Song, Xinyi ; Yu, Tingli; Zhang, Jiao; Li, Yiping; He, Zeyuan;  E， Ruiyao; Miao, Xiaokang; Xie, Junqiu; Ni, Jingman*; Wang, Rui*; Sun, Wangsheng*；CCS Chem.，2024，6（6），1547-1556。（IF = 9.4）

6.    Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections，Guo, Xiaomin; Miao, Xiaokang; An, Yingying; Yan, Tiantian; Jia, Yue; Deng, Bochuan; Cai, Jianfeng; Yang, Wenle; Sun, Wangsheng*; Wang, Rui*; Xie, Junqiu*；Eur. J.  Med. Chem.，2024，264，116001。（IF = 6.0）

7.    Novel Feleucin-K3-Derived Peptides Modified with Sulfono-γ-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin- Resistant Staphylococcus aureus Infections，Guo, Xiaomin; Yan, Tiantian; Rao, Jing; An, Yingying; Yue, Xin; Miao, Xiaokang; Wang, Rui; Sun, Wangsheng*; Cai, Jianfeng*; Xie, Junqiu*；J. Med. Chem.，2023，66（2），1254-1272。（IF = 6.8）

8.    NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization，Li, Yiping; Li, Jingyue; Bao, Guangjun; Yu, Changjun; Liu, Yuyang; He, Zeyuan; Wang, Peng; Ma, Wen; Xie, Junqiu; Sun, Wangsheng*; Wang, Rui*；Org. Lett.，2022，24（5），1169-1174。（IF = 4.9）

9.    1,3-Dipolar Cycloaddition between Dehydroalanines and C,N-Cyclic Azomethine Imines: Application to Late-Stage Peptide Modification，Bao, Guangjun; Wang, Peng; Li, Guofeng; Yu, Changjun; Li, Yiping; Liu, Yuyang; He, Zeyuan; Zhao, Tiantian; Rao, Jing; Xie, Junqiu; Hong, Liang; Sun, Wangsheng*; Wang, Rui*；Angew. Chem. Int. Ed.，2021，60（10），5331-5338。（IF = 16.1）

10. Organocatalytic Enantioselective Synthesis of Tetrasubstituted α-Amino Allenoates by Dearomative γ-Addition of 2,3-Disubstituted Indoles to β,γ-Alkynyl-α-imino Esters，Yang, Junxian; Wang, Zheng; He, Zeyuan; Li, Guofeng; Hong, Liang; Sun, Wangsheng*； Wang, Rui*；Angew. Chem. Int. Ed.，2020，59（2），642-647。（IF = 16.1）