职 务：医学生物化学与分子生物学教研室主任
职 称：教授、博士生导师
电子邮箱：wangkr@lzu.edu.cn
科研方向：抗菌肽的药物化学和生物化学研究、基于多肽的抗菌创新药物发现和基于多肽的生物医学材料研究
王凯荣，男，博士，教授，博士研究生导师。 2009 年于兰州大学获得理学博士学位，专业为生物化学与分子生物学，同年留校。2016年，在国家公派高级研究学者及访问学者(含博士后)项目资助下，在荷兰伊拉斯姆斯大学医学中心Luc van der Laan实验室从事1年的访问学者研究。
目前在兰州大学基础医学院医学生物化学与分子生物学研究所从事教学、科研工作;主要研究领域为药物化学和生物化学;主要承担本科生《生物化学与分子生物学》 《生物化学与分子生物学实验》等专业基础课程的教学工作;指导本科生校级和国家级大学生创新创业训练计划创新训练项目多项。
主要从事抗菌肽的药物化学和生物化学研究、基于多肽的抗菌创新药物发现(抗菌肽药物分子设计、合成及抗菌肽抗肿瘤、抗菌、抗真菌活性、作用机制及构效关系研究)和基于多肽的生物医学材料研究。相关研究工作已发表SCI研究论文50余篇;当前主持在研国家自然科学基金面上项目1项，甘肃省自然科学基金一般项目1项及横向项目2项;已主持完成国家自然科学基金面上项目1项，国家自然科学基金青年基金项目1项，教育部博士点新教师基金项目1项，教育部“春晖计划”合作项目2项;参与完成 “国家科技重大专项”项目2009ZX09503-017和2012ZX09504001-003的完成;参与完成国家自然科学基金重大研究计划1项(91413107)等; 2013年8月获“中国药学会科学技术奖一等奖”(8/15); 2012年获第十二届中国国际多肽学术会议青年论文奖(Young Peptide Scienctist Award); 2013年10月获第十二届张锡均基金会全国青年优秀生理学学术论文优秀口头报告奖(中国生理学会);
邮箱: wangkr@lzu.edu.cn
教育、研究工作经历：
2000.9-2004.7 西北师范大学生命科学学院，获得学士学位。
2004.9-2009.7 兰州大学生命科学学院，生物化学与分子生物学专业，获得博士学位。
2009.7—2012.5 兰州大学，基础医学院,讲师;
2012.5—2017.6 兰州大学，基础医学院，副教授，硕士生导师。
2015.12-2016.12 Erasmus University, Medical Center, Research Fellow，合作导师：Luc van der Laan
2017.7-——2018.6 兰州大学，基础医学院，副教授，博士研究生导师。
2018.7-- 兰州大学，基础医学院，教授，博士研究生导师。
主要从事抗菌肽的药物化学和生物化学研究、基于多肽的抗菌创新药物发现(抗菌肽药物分子设计、合成及抗菌肽抗肿瘤、抗菌、抗真菌活性、作用机制及构效关系研究)和基于多肽的生物医学材料研究。
主持项目：
1. 国家自然科学基金面上项目, “基于环肽抗生素lugdunin的全新抗菌多肽的设计、合成及抗菌活性研究”， (No. 82073679) 2021.1-2014.12. 在研；
2. 甘肃省自然科学基金一般项目，“基于“侧链微修饰“策略的高稳定抗菌肽构建及抗菌作用、构效关系研究”，（No. 20JR5RA245）2020.11-2022.10. 在研；
3. 中央高校基本科研业务费专项资金自由探索项目“超短序列抗菌肽Jelleine-1抗真菌活性、作用机制及构效关系研究”，（lzujbky-2017-128）2017.1-2018.12；已结题；
4. 教育部“春晖计划”合作科研项目“赖氨酸侧链修饰的抗菌肽protonectin衍生物的稳定性、抗菌活性及作用机制研究”，（Z2016002），2016.12-2018.12；已结题；
5. 国家自然科学基金面上项“化学修饰策略构建高稳定性抗菌肽polybia-CP衍生物及其抗真菌活性研究”（No. 81573265）, 2016.1-2017.12；已结题；
6. 中央高校基本科研业务费专项资金自由探索项目“具临床应用潜力的限制性结构抗菌肽polybia-CP衍生物的设计、合成及抗真菌活性研究”（lzujbky-2015-155），2015.1-2016.6；已结题；
7. 中央高校基本科研业务费专项资金自由探索项目“赖氨酸侧链修饰的抗菌肽protonectin衍生物的稳定性、抗菌活性及作用机制研究” （lzujbky-2015-279），2015.7-2016.12；已结题；
8. 兰州大学中央高校自由探索面上项目“新型抗菌肽氟代衍生物抗真菌活性、作用机制及构效关系研究”(No.lzujbky-2013-164)，2013.1-2014.6；已结题；
9. 国家自然科学基金青年基金项目“以细胞膜为靶标的新型抗菌肽polybia-MPI类似物的设计、合成及抗菌活性研究”（No.31200584）, 2013.01-2015.12；已结题；
10. 教育部博士点新教师基金项目“抗菌肽polybia-MPI 的新型类似物的设计合成、抗菌活性及构效关系研究”（No.20120211120045）， 2013.1-2015.12；已结题；
11. 教育部“春晖计划”合作科研项目“抗菌肽优化设计合成、构效关系及膜-肽作用分子动力学机制研究”（No.Z2010082）， 2011.7—2013.7；已结题；
12. 兰州大学中央高校自由探索面上项目“免疫蛋白NK-lysin衍生的抗菌肽在耐药病菌、流感病毒感染治疗中的应用研究”(No.lzujbky-2010-129)，2010.7-2011.7；已结题；
已发表论文目录（第一作者和通讯作者）:
1. Zhang H, Wu Z, Zhou J, Wang Z, Yang C, Wang P, Fareed MS, He Y, Su J, Cha R*, Wang Kairong*. The Antimicrobial, Hemostatic, and Anti-Adhesion Effects of a Peptide Hydrogel Constructed by the All-d-Enantiomer of Antimicrobial Peptide Jelleine- Advanced Healthcare Materials. 2023:e2301612. doi: 10.1002/adhm.202301612. (IF2022 10.0)
2. Zhou J; Cha R*; Wu Z; Zhang C; He Y; Zhang H; Liu K; Fareed MS; Wang Z; Yang C; Zhang Y; Yan W*; Wang Kairong*; An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects, Nano Today, 2023, 49: 101801. (IF2021 18.962)
3. Teng P*, Shao H, Huang B, Xie J, Cui S*, Wang Kairong*, Cai J*. Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance. J. Med. Chem., 2023;66:2211-34. (IF2021 8.039)
4. Zhou J, Wang Z, Yang C, Zhang H, Fareed MS, He Y, Su J, Wang P, Shen Z, Yan Wenjin*, Wang Kairong*. A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing. Acta Biomater. 2022, 151: 223-234. (IF2021 10.633)
5. Zhou J, Zhang H, Fareed MS, He Y, Lu Y, Yang C, Wang Z, Su J, Wang P, Yan W*, Wang Kairong*. An Injectable Peptide Hydrogel Constructed of Natural Antimicrobial Peptide J-1 and ADP Shows Anti-Infection, Hemostasis, and Antiadhesion Efficacy. ACS Nano. 2022;16(5): 7636-7650. （IF2021 18.027）
6. Liang X, Liu K, Zhao P, Zhou J, Zhang F, He Y, Zhang H, Fareed MS, Lu Y, Xu Y, Zhang Z, Yan W*, Wang Kairong*. The effects of incorporation of the counterparts and mimics of L-lysine on the antimicrobial activity, hemolytic activity, cytotoxicity and tryptic stability of antimicrobial peptide polybia-MPII. Amino Acids. 2022;54(1):123-135.
7. Chen Q, Yang C, Xie Y, Wang Y, Li X*, Wang Kairong*, Huang J*, Yan W*. GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences. J Chem Inf Model. 2022;23;62(10): 2617- 2629. (IF2021 6.162)
8. H Sheng, J Zhou, B Li, Y He, X Zhang, J Liang, J Zhou, Q Su, E Xie, Wei Lan*, Kairong Wang*, Cunjiang Yu*. A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body. Science Advance 2021;7(2):eabe3097. （IF2021 14.957）
9. Zhou J, Zhang L, He Y, Liu K, Zhang F, Zhang H, Lu Y, Yang C, Wang Z, Fareed MS, Liang X*, Yan W*, Wang Kairong*. An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. Eur J Med Chem. 2021;219:113433. （IF2021 7.088）
10. Y Deng, Z Dong, F Gao, Y Guo, M Sun, Y Li, Y Wang, Q Chen, Kairong Wang, W Yan. The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction. J Org Chem. 2021;86(18):13011-13024.
11. F Gao, B Li, Y Wang, Q Chen, Y Li, Kairong Wang*, Wenjin Yan*. Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group. Org. Chem. Front., 2021;8, 2799-2819. (IF2021 5.456)
12. Jia F, Wang J, Zhang L, Zhou J, He Y, Lu Y, Liu K, Yan W*, Wang Kairong*. Multiple action mechanism and in vivo antimicrobial efficacy of antimicrobial peptide Jelleine-I. J Pept Sci. 2021;27(3):e3294.
13. Peng J, Qiu S, Jia F, Zhang L, He Y, Zhang F, Sun M, Deng Y, Guo Y, Xu Z, Liang X, Yan W*, Wang Kairong*. The introduction of L-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria. Amino Acids. 2021;53(1):23-32.
14. F Jia, X Liang, J Wang, L Zhang, J Zhou, Y He, F Zhang, Wenjin Yan* Kairong Wang*. Tryptic Stability and Antimicrobial Activity of the Derivatives of Polybia‑CP with Fine‑Tuning Modification in the Side Chain of Lysine. Int J Pept Res Ther., 2021, 27(2):1-12.
15. Peng J, Yang Y, Zhao P, Qiu S, Jia F, Wang J, Liang X, Chaudhry AS, Xu P, Yan W, Xu Z*, Wang K*. Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. Acta Biochim Biophys Sin (Shanghai). 2020;52(6):603-611.
16. B Li, F Gao, X Feng, M Sun, Y Guo, D Wen, Y Deng, J Huang, Kairong Wang*, Wenjin Yan*. Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition. Org. Chem. Front., 2019,6, 1567-1571. (IF2021 5.456)
17. Li B, Liu J, Gao F, Sun M, Guo Y, Zhou Y, Wen D, Deng Y, Chen H, Wang K, Yan W. The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition. Org Biomol Chem. 2019;17(11):2892-2895.
18. Wang C, Wen D, Chen H, Deng Y, Liu X, Liu X, Wang L, Gao F, Guo Y, Sun M, Wang Kairong*, Yan W*. The catalytic asymmetric synthesis of CF3-containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition. Org Biomol Chem. 2019;17(22):5514-5519.
19. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, w Yan*, R Wang*. The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species. Amino Acids. 2018;50(2):229-239.
20. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, W Yan*, R Wang*. D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. Acta Biochim Biophys Sin. 2017;49(10):916-925.
21. Q Shuai, R Zhu, Y Zhao, X An, F Jia, J Peng, Z Ma, Y Zhu, J Wang, J Su, Q Wang, H Wan, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of protonectin with D-amino acid substitutions, J Pept Sci., 2017; 23(5):392-402.
22. Z Dong, Y Zhu, B Li, C Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*, Asymmetric Synthesis of #-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction. J Org Chem., 2017; 2017;82(7):3482-3490.
23. Y Zhao, M Zhang, S Qiu, J Wang, J Peng, P Zhao, R Zhu, H Wang, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI. AMB Express, 2016; 6(1):122.
24. J Su, Z Ma, X Li, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*，Asymmetric Synthesis of 2′-Trifluoromethylated Spiro-pyrrolidine-3,3′-oxindoles viaSquaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition. Advanced Synthesis & Catalysis, 2016;358:3777-3785. (IF2021 5.981)
25. Y Zhu, Z Dong，X Cheng, X Zhong, X Liu, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction. Organic Lett, 2016;18(15):3546-3549. (IF2021 6.072)
26. X Li, J Su, Z Liu, Y Zhu, Z Dong, S Qiu, J Wang, L Lin, Z Shen, Wenjin Yan*, Kairong Wang*, Rui Wang*, Synthesis of Chiral α-Trifluoromethylamines with 2, 2,2-Trifluoroethylamine asa ‘Building Block’. Organic Lett., 2016;18(5):956-959. (IF2021 6.072)
27. Kairong Wang, F Jia , W Dang, Y Zhao, R Zhu, M Sun, S Qiu, X An, Z Ma, Y Zhu, J Yan, Z Kong, Wenjin Yan* , Rui Wang*. Antifungal effect and action mechanism of antimicrobial peptide polybia-CP. J Pept Sci., 2016;22(1):28-35.
28. Y Zhu, X Li, Q Chen, J Su, F Jia, S Qiu, M Ma, Q Sun, Wenjin Yan*, Kairong Wang*, Rui Wang*, Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-containing Chromanes. Organic Lett., 2015;17(15): 3826-3829. (IF2021 6.072)
29. Q Sun, X Li, J Su, L Zhao, M Ma, Y Zhu, Y Zhao, R Zhu, Wenjin Yan*, Kairong Wang*, Rui Wang. The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5'-Trifluoromethyl-spiro[pyrrolidin-3,2'-oxindoles]. Advanced Synthesis & Catalysis, 2015;357(14-15):3187-3196. (IF2021 5.981)
30. M Ma, Y Zhu, Q Sun, X Li, J Su, L Zhao, Y Zhao, S Qiu, Wenjin Yan*, Kairong Wang*, Rui Wang*. The Asymmetric Synthesis of CF3- containing Spiro[pyrrolidin-3,2’-oxindole] through the Organocatalytic 1, 3-dipolar Cycloaddition Reaction. Chem. Comm.，2015;51(42):8789-8792. (IF2021 6.065)
31. Kairong Wang, W Dang, J Xie, R Zhu, M Sun, F Jia, Y Zhao, X An, S Qiu, X Li, Z Ma, Wenjin Yan*, Rui Wang*. Antimicrobial peptide protonectin disturbs the membrane integrity andinduces ROS production in yeast cells，Biochimica et Biophysica Acta-Biomembranes. 2015;1848(10):2365-2373.
32. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 56：22-29.
33. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrob. Agents Chemother., 2013,57(10), 4632–9. (IF2021 5.938)
34. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88.
35. J Yan1, Kairong Wang1, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (IF2021 5.938)
36. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. (IF2021 5.938)
37. J Yan1, Kairong Wang1, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie 2012,94 184-191.
38. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33.
39. B Zhang1, Kai-rong Wang1, W Zhang, J Yan, J Song, Rui Wang. In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573.
40. Kairong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett., 2009, 278,65-72. (IF2021 9.756)
41. Kairong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett., 2008,268,38-45. (IF2021 9.756)
42. Kairong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8.
学院地址: 甘肃省兰州市东岗西路199号 兰州大学基础医学院 邮编: 730000
电 话: 0931-8915023 8915092
传真: 0931-8915023
电子邮箱: jcyxy@lzu.edu.cn
