药物化学和生物医学材料（主要从事抗菌肽、抗菌创新药物发现、及生物医学功能材料研究）。

已发表论文目录（第一作者和通讯作者）:

1. Y He, Y Yang, M Li, Y Ren, J Su, Q Ji, MS Fareed, Z Shen, P Wang, J Yan*, Kairong Wang*. Cationizing Lugdunin through Trp3 Hydrophobic Fine-Tuning and Cationic Side Chain Engineering.J. Med. Chem, 2026. doi.org/10.1021/acs.jmedchem.5c02219.  (IF 6.8)

2. MS Fareed, M Li, Y He, J Su, Q Ji, Y Ren, Z Wang, Z Xu, D Wan, S Liang, X Miao, Y Li, Y Zhou*, Kairong Wang*.  Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria. Eur J Med Chem. 2026, 301, 118182. (IF 2024 5.9)

3. J Yuan, Z Wang, D Xia, H Sheng, Q Wang, J Hu, L Ma, F Li, H Bi, H Zhang, Do Wan, W Li , Z Xie*, Kairong Wang* , W Lan*. A stretchable, wirelessly rechargeable, body-integrated energy supply system with on-demand energy release. Nano Energy, 2025, 135, 110612. (IF 17.1)

4. L Xu, Z Chen, D Tang, Q Yin, C Tao*, Kairong Wang*. Research on the fabrication and properties of injectable antimicrobial hydrogels composed of mesoporous polydopamine. Colloid and Polymer Science. 2025, 303(12), 2641-2656.

5. H Bi, Z Wang, H Sheng, M Shang, J Hu, C Guo, D Wan, F Li, Q Yue, Q Su, Z Li*, Kairong Wang*, W Lan*.A Flexible Bioresorbable Implantable Sensor for Wireless Dynamic Monitoring of H2O2 Enabled by Pt-Decorated MoO3-x Nanozyme. Small, 2025, 21, e08861. DOI: 10.1002/smll.202508861. (IF 12.1)

6. W Zhu, X Bao, Y Yang, M Xing, S Xiong, S Chen, Y Zhong, X Hu, Q Lu, Kairong Wang*, Q Ling*, S Cui*. Peripheral Evolution of Tanshinone IIA and Cryptotanshinone for Discovery of a Potent and Specific NLRP3 Inflammasome Inhibitor. J. Med. Chem. 2025, 68, 3, 3460–3479. (IF 6.8)

7. Y He, J Su, M Li, MS. Fareed, Y Ren, P Wang, Z Wang, D Wan, T Ma, W Yan*, H Zhang*, Kairong Wang*. Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations. J. Med. Chem. 2025, 68, 5, 5699–5718. (IF 6.8)

8. Q Wen, Y He, J Chi, L Wang, Y Ren, X Niu, Y Yang, K Chen, Q Zhu, J Lin, Y Xiang, J Xie, W Chen, Y Yu, B Wang, B Wang*, Y Zhang*, C Lu*, Kairong Wang*, P Teng*, R Zhou. Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance. Eur J Med Chem.2025,289, 117496. (IF 5.9)

9. Z Wang, T Ma, D Wan, Z Xu, S Liang, Z Wu, Y He, MS Fareed, M Li, Y Ren, Q Ji, H Zhang*, Kairong Wang*. A Self-Assembled Jelleine-1 Nanoscale Hydrogel Boosted by Ascorbate for Atopic Dermatitis Therapy with Dual Antibacterial and Antioxidant Efficacy. ACS Appl. Nano Mater. 2025, 8, 35, 17231–17246. (IF 5.5)

10. Y He,M Li, J Su, Y Ren, MS Fareed, Z Shen, P Wang, Q Ji, Z Wang, D Wan, T Ma, J Yan*, Kairong Wang*. Expanding the antimicrobial spectrum of lugdunin: Discovery of multi-cationic derivatives of lugdunin with antimicrobial activity against gram-positive and gram-negative bacteria. Eur。J. Med. Chem, 2025, 299,  118078. (IF 5.9)

11. J Su, Y He, M Li, Z Shen, Q Ji, Y Ren, MS Fareed, Kairong Wang*. Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria.Bioorganic Chemistry. 2025, 165, 108990. (IF 4.7)

12. S Li, Z Wang, S Song, Y Tang, J Zhou, X Liu, X Zhang, M Chang, Kairong Wang*, Yali Peng*. Membrane-Active All-Hydrocarbon-Stapled α-Helical Amphiphilic Tat Peptides: Broad-Spectrum Antibacterial Activity and Low Incidence of Drug Resistance. ACS Infect. Dis. 2024, 10, 5, 1839-1855. (IF 3.8)

13. K Liu, H Zhang, Z Wang, J Zhou, Y He, J Li, X Wang, J Su, P Wang, Z Shen, MS Fareed, D Wan, T Ma, M Li, Y Li, J Zhang*, Kairong Wang*. Carrier-Free, Injectable Hydrogel Formed by Self-Assembled Nanofibers of Antimicrobial and Anti-inflammatory Peptide for Wound Healing. ACS Appl. Nano Mater. 2024, 7, 14, 16585–16598. (IF 5.5)

14. Zhou J; Cha R*; Wu Z; Zhang C; He Y; Zhang H; Liu K; Fareed MS; Wang Z; Yang C; Zhang Y; Yan W*; Wang Kairong*; An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects, Nano Today, 2023, 49: 101801. (IF2021 18.962)

15. Teng P*, Shao H, Huang B, Xie J, Cui S*, Wang Kairong*, Cai J*. Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance. J. Med. Chem., 2023;66:2211-34. (IF2021 8.039)

16. Zhou J, Wang Z, Yang C, Zhang H, Fareed MS, He Y, Su J, Wang P, Shen Z, Yan Wenjin*, Wang Kairong*. A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing. Acta Biomater. 2022, 151: 223-234. (IF2021 10.633)

17. Zhou J, Zhang H, Fareed MS, He Y, Lu Y, Yang C, Wang Z, Su J, Wang P, Yan W*, Wang Kairong*. An Injectable Peptide Hydrogel Constructed of Natural Antimicrobial Peptide J-1 and ADP Shows Anti-Infection, Hemostasis, and Antiadhesion Efficacy. ACS Nano. 2022;16(5): 7636-7650. （IF2021 18.027）

18. Liang X, Liu K, Zhao P, Zhou J, Zhang F, He Y, Zhang H, Fareed MS, Lu Y, Xu Y, Zhang Z, Yan W*, Wang Kairong*. The effects of incorporation of the counterparts and mimics of L-lysine on the antimicrobial activity, hemolytic activity, cytotoxicity and tryptic stability of antimicrobial peptide polybia-MPII. Amino Acids. 2022;54(1):123-135.

19. Chen Q, Yang C, Xie Y, Wang Y, Li X*, Wang Kairong*, Huang J*, Yan W*. GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences. J Chem Inf Model. 2022;23;62(10): 2617- 2629. (IF2021 6.162)

20. H Sheng, J Zhou, B Li, Y He, X Zhang, J Liang, J Zhou, Q Su, E Xie, Wei Lan*, Kairong Wang*, Cunjiang Yu*. A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body. Science Advance 2021;7(2):eabe3097. （IF2021 14.957）

21. Zhou J, Zhang L, He Y, Liu K, Zhang F, Zhang H, Lu Y, Yang C, Wang Z, Fareed MS, Liang X*, Yan W*, Wang Kairong*. An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. Eur J Med Chem. 2021;219:113433.（IF2021 7.088)

22. F Gao, B Li, Y Wang, Q Chen, Y Li, Kairong Wang*, Wenjin Yan*. Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group. Org. Chem. Front., 2021;8, 2799-2819. (IF2021 5.456

23. Jia F, Wang J, Zhang L, Zhou J, He Y, Lu Y, Liu K, Yan W*, Wang Kairong*. Multiple action mechanism and in vivo antimicrobial efficacy of antimicrobial peptide Jelleine-I. J Pept Sci. 2021;27(3):e3294.

24. Peng J, Qiu S, Jia F, Zhang L, He Y, Zhang F, Sun M, Deng Y, Guo Y, Xu Z, Liang X, Yan W*, Wang Kairong*. The introduction of L-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria. Amino Acids. 2021;53(1):23-32.

25. F Jia, X Liang, J Wang, L Zhang, J Zhou, Y He, F Zhang, Wenjin Yan* Kairong Wang*. Tryptic Stability and Antimicrobial Activity of the Derivatives of Polybia‑CP with Fine‑Tuning Modification in the Side Chain of Lysine. Int J Pept Res Ther., 2021, 27(2):1-12.

26. Peng J, Yang Y, Zhao P, Qiu S, Jia F, Wang J, Liang X, Chaudhry AS, Xu P, Yan W, Xu Z*, Wang K*. Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. Acta Biochim Biophys Sin (Shanghai). 2020;52(6):603-611.

27. B Li, F Gao, X Feng, M Sun, Y Guo, D Wen, Y Deng, J Huang, Kairong Wang*, Wenjin Yan*. Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition. Org. Chem. Front., 2019,6, 1567-1571. (IF2021 5.456)

28. Li B, Liu J, Gao F, Sun M, Guo Y, Zhou Y, Wen D, Deng Y, Chen H, Wang K, Yan W. The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition. Org Biomol Chem. 2019;17(11):2892-2895.

29. Wang C, Wen D, Chen H, Deng Y, Liu X, Liu X, Wang L, Gao F, Guo Y, Sun M, Wang Kairong*, Yan W*. The catalytic asymmetric synthesis of CF3-containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition. Org Biomol Chem. 2019;17(22):5514-5519.

30. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, w Yan*, R Wang*. The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species. Amino Acids. 2018;50(2):229-239. 

31. F Jia, J Wang, J Peng, P Zhao, Z Kong, Kairong Wang*, W Yan*, R Wang*. D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. Acta Biochim Biophys Sin. 2017;49(10):916-925. 

32. Q Shuai, R Zhu, Y Zhao, X An, F Jia, J Peng, Z Ma, Y Zhu, J Wang, J Su, Q Wang, H Wan, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of protonectin with D-amino acid substitutions, J Pept Sci., 2017; 23(5):392-402.

33. Z Dong, Y Zhu, B Li, C Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*, Asymmetric Synthesis of #-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction. J Org Chem., 2017; 2017;82(7):3482-3490.  

34. Y Zhao, M Zhang, S Qiu, J Wang, J Peng, P Zhao, R Zhu, H Wang, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI. AMB Express, 2016; 6(1):122.

35. J Su, Z Ma, X Li, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*，Asymmetric Synthesis of 2′-Trifluoromethylated Spiro-pyrrolidine-3,3′-oxindoles viaSquaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition. Advanced Synthesis & Catalysis, 2016;358:3777-3785. (IF2021 5.981)

36. Y Zhu, Z Dong，X Cheng, X Zhong, X Liu, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction. Organic Lett, 2016;18(15):3546-3549. (IF2021 6.072)

37. X Li, J Su, Z Liu, Y Zhu, Z Dong, S Qiu, J Wang, L Lin, Z Shen, Wenjin Yan*, Kairong Wang*, Rui Wang*, Synthesis of Chiral α-Trifluoromethylamines with 2, 2,2-Trifluoroethylamine asa ‘Building Block’. Organic Lett., 2016;18(5):956-959. (IF2021 6.072)

38. Kairong Wang, F Jia , W Dang, Y Zhao, R Zhu, M Sun, S Qiu, X An, Z Ma, Y Zhu, J Yan, Z Kong, Wenjin Yan* , Rui Wang*. Antifungal effect and action mechanism of antimicrobial peptide polybia-CP.  J Pept Sci., 2016;22(1):28-35. 

39. Y Zhu, X Li, Q Chen, J Su, F Jia, S Qiu, M Ma, Q Sun, Wenjin Yan*, Kairong Wang*, Rui Wang*, Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-containing Chromanes. Organic Lett., 2015;17(15): 3826-3829. (IF2021 6.072)

40. Q Sun, X Li, J Su, L Zhao, M Ma, Y Zhu, Y Zhao, R Zhu, Wenjin Yan*, Kairong Wang*, Rui Wang*. The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5'-Trifluoromethyl-spiro[pyrrolidin-3,2'-oxindoles]. Advanced Synthesis & Catalysis, 2015;357(14-15):3187-3196. (IF2021 5.981)

41. M Ma, Y Zhu, Q Sun, X Li, J Su, L Zhao, Y Zhao, S Qiu, Wenjin Yan*, Kairong Wang*, Rui Wang*. The Asymmetric Synthesis of CF3- containing Spiro[pyrrolidin-3,2’-oxindole] through the Organocatalytic 1, 3-dipolar Cycloaddition Reaction. Chem. Comm.，2015;51(42):8789-8792. (IF2021 6.065)

42. Kairong Wang, W Dang, J Xie, R Zhu, M Sun, F Jia, Y Zhao, X An, S Qiu, X Li, Z Ma, Wenjin Yan*, Rui Wang*. Antimicrobial peptide protonectin disturbs the membrane integrity andinduces ROS production in yeast cells，Biochimica et Biophysica Acta-Biomembranes. 2015;1848(10):2365-2373.

43. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 56：22-29.

44. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrob. Agents Chemother., 2013,57(10), 4632–9. (IF2021 5.938)

45. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang*. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88.

46. J Yan¹, Kairong Wang¹, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang*. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (IF2021 5.938)

47. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang*. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. (IF2021 5.938)

48. J Yan¹, Kairong Wang¹, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang*. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie 2012,94 184-191.

49. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33.

50. B Zhang¹, Kai-rong Wang¹, W Zhang, J Yan, J Song, Rui Wang*. In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573.

51. Kairong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang*. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett., 2009, 278,65-72. (IF2021 9.756)

52. Kairong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett., 2008,268,38-45. (IF2021 9.756)

53. Kairong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang*. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8.

授权国家发明专利：

1. 王凯荣，贺宇航，苏洁：“小分子肽模拟物及其应用”：国家发明专利，专利号: ZL 202410013060.0,授权公告日：2025.02.18。

2. 王凯荣，苏洁，贺宇航，李敏：“基于金刚烷修饰的抗菌肽模拟物及其应用” ：国家发明专利，专利号：ZL 202510275595.X，授权公告日：2025.11.11。

3. 滕鹏，王凯荣，温琪，陆超，张颖，徐易尘：“一种环丙沙星衍生物及其制备方法和应用” ，专利号：ZL CN202411828900.5，授权公告日：2025.11.21

申请国家发明专利：

1. 王凯荣，穆罕默德·苏班·法里德，贺宇航，李敏，冀清贤，任怡璇：“一种脂肪化阳离子两亲性肽模拟物及其制备方法和应用”：申请号：N202510925347.5，申请日期：2025.07.05。

2. 王凯荣，王兆鹏，马婷，万代草：“一种多肽自组装水凝胶及其制备方法”：申请号： CN202510636400.X。申请日期：2025.05.16

3. 王凯荣，贺宇航，苏洁，李敏：“基于Lugdunin的新型阳离子环肽抗生素”：申请号：CN202411535529.3。申请日期：2024.10.31。

4. 崔孙良，朱文琪，王凯荣，鲍小栋：“丹参酮IIA、隐丹参酮酰胺衍生物的制备方法和应用”，申请号： CN202410340478.2。申请日期：2024.03.25。公开日：2025.09.26

5. 王凯荣，王兆鹏，万代草：“一种多糖-抗菌肽共组装水凝胶的制备及其应用”，申请号：202610012190.1。  申请日期：2026.01.06。