不对称催化，手性药物合成及药理学研究

主持的在研项目

1.中央高校基本科研业务费“含α-CF3胺结构单元的氨基酸的合成研究” (lzujbky-2013-168 )， 2013.1-2014.6

2. 国家自然科学基金面上项目“3-烷氧羰基靛红亚胺的合成及其在合成手性双取代3-氨基氧化吲哚化合物方面的应用 ” ( No. 21272108 ), 2013-2016

代表性论著:

1.Dong Wang1, Jinyan Liang1, Jingchao Feng, Kairong Wang, Quantao Sun, Long Zhao, Dan Li, Wenjin Yan*, Rui Wang*(The Quinine Thiourea-catalyzed Asymmetric Strecker Reaction: An Approach for the Synthesis of 3-Aminooxidoles)advanced Synthesis & Catalysis 2013,355:548-58. (SCI 二区, IF 6.048)

2. Jingchao Feng, Wenjin Yan, Dong Wang, Peng Li, Quantao Sun， Rui Wang (The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids) Chem. Commun., 2012, 48, 8003. (SCI二区, IF 6.169)

3. Wenjin Yan, Dong Wang, Jingchao Feng, Peng Li, Rui Wang (The Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatin and Their Application in Enantioselective Transformations) Org . Lett. 2012, 14, 2512 (SCI二区, IF 5.862)

4. Wenjin Yan; Dong Wang, Jingchao Feng, Peng Li, Rui Wang(Zinc-Mediated Diastereoselective Synthesis of 3-Amino Oxindoles by Addition of Methyl and Terminal Alkynes to N-tert-Butanesulfinyl Ketimines) J. Org. Chem. 2012, 2012, 77, 3311. (SCI二区, IF 4.45).

5.Wenjin Yan, Peng Li, Jingchao Feng, Dong Wang, Xianxing Jiang,Shaoqun Zhu, and Rui Wang (Design and Synthesis of Tridentate Ligand Inspired by the Phenomenon of Self-assembly Catalysis and its Application in Asymmetric Alkynylation of N-(diphenylphosphinoyl) Imines) Tetrahedron: Asymmetry 2010, 2037-2042. (SCI三区, IF 2.625).

6.Shaoqun Zhu, Wenjin Yan, Bin Mao, Xianxing Jiang, Rui Wang. Enantioselective Nucleophilic Addition of Trimethylsilylacetylene to N-Phosphinoylimines Promoted by C2-Symmetric Proline–Derivatived β-Amino Alcohol. J. Org. Chem. 2009, 6980-6985. (SCI二区, IF 4.45)

7.Wenjin Yan, Bin Mao, Shaoqun Zhu, Xianxing Jiang, Zhongli Liu, and Rui Wang. Asymmetric Addition of Terminal Alkynes to N-(diphenylphosphinoyl) Imines Promoted by Stoichiometric Amount Proline-Derived β-Amino Alcohol. Eur. J. Org. Chem. 2009, 3790-3794.

(SCI三区, IF 3.20 )

8. K Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, Wenjin Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88. (SCI三区，IF=2.421)