膜生物物理与化学生物学;膜受体靶向新药创制

——聚焦神经、免疫与心血管系统重大疾病相关膜蛋白跨膜信号转导过程中的关键生物物理问题，疾病的发病机制，新药候选分子发现及新技术、新方法的建立等方面的研究。

近3年部分已发表论文：

[1] Sun MY, Bian YJ, Chen XY, Zhang X, Li M, Zhou BY, Yang Y, Huang YZ, Yang R, Gao YH, Cui WW, Wang YQ, Zhu SJ, Cao P, Li CZ, Zhu MX, Lei YT, Yang F, Yu Y^#. Mechanism of capsaicin entry into buried vanilloid sites in TRPV1. Nat Chem Biol. 2025 Dec;21(12):1957-1969. doi: 10.1038/s41589-025-01966-5

[2] Lu Y, Yue C, Zhang L, Yao D, Xia Y, Zhang Q, Zhang X, Li S, Shen Y, Cao M, Guo C, Qin A, Zhao J, Zhou L, Yu Y^#, Cao Y^#. Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1, Science, 2024, 386(6723): eadp3252.

[3] Huang Y, Ma J, Bian Y, Bai Q, Gao Y, Di S, Lei Y, Yang H, Yang X, Shao C, Wang W, Cao P, Li C, Zhu M. X, Sun M^#, Yu Y^#. TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception, Neuron, 2024, 112(11):1815-1831.

[4] Guo CR, Sheng D, Li JY, Li TT, Yao JB, Zhang R, Huang Y, Zhao YY, Wang DP, Chen J, Li J, Wang J, Zhou Y, Shen C, Jin F, Cao P, Hattori M, Liu H, Yu Y^#. Understanding interspecies drug response variations between human and rodent P2X7 receptors. Nat Commun. 2025 Dec 2;16(1):10827. doi: 10.1038/s41467-025-65847-0.

[5] Yu PC, Yue CX, Dong WZ, Hao CY, Qiao YF, Liu D, Zhang X, Zhan Q, Yao JB, Wang DP, Cao P, Fan YZ, Yu Y^#. Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface.  Adv Sci (Weinh). 2025 Oct 30:e01602. doi: 10.1002/advs.202501602

[6] Lin Y, Lu Y, Li C, Ma X, Shao M, Gao Y, Zhang Y, Jiang H, Liu Y, Yang Y, Huang L, Cao P, Wang H, Wang J^#, Yu Y^#. Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. Nat Commun, 2024, 15(1):7652.

[7] Gao YH, Huang YZ, Li ZX, Chen XY, Shao CY, Li HW, Liu B, Yang F, Chen MR, Lu ML, Zhu MX, Yang F, Xiao YB, Yu Y^#. Structures of TRPV1 bound by hyperthermia-inducing analgesics. Cell Rep. 2025 Dec 24;45(1):116765. doi: 10.1016/j.celrep.2025.116765

[8] Endogenous forms of ATP-ATP4- and MgATP2--orchestrate distinct pathophysiological signaling via biased activation of P2X3 receptors. Wang J, Guan L, Wang TT, Xie TX, Lin YY, Sun MY, Wang DP, Zhang X, Bian YJ, Yue CX, Ding BB, Ma XF^#, Yu Y^#. PNAS, 2025 Dec 16;122(50):e2504688122.

[9]. Mechanistic insights into ligand selectivity in μ- and δ-opioid receptors beyond the “message–address” conceptual framework. Xin Zhang, Hongyan Song, Ruofan Chen, Xinran Kong, Jin Wang^#, Xinghua Li ^#, Yu Y^#. Acta Pharm Sin B. 2025. Online.

[10] Guo C, Zhang Z, Zhou X, Sun M, Li T, Lei Y, Gao Y, Li Q, Yue C, Gao Y, Lin Y, Hao C, Li C, Cao P, Zhu M. X, Rong M^#, Wang W^#, Yu Y^#. Chronic cough relief by allosteric modulation of P2X3 without taste disturbance, Nat Commun, 2023, 14(1): 5844.