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副教授/副研究员

苏刚

职　　务：遗传学教研室副主任

职　　称：副教授、硕士生导师

电子邮箱：sugang@lzu.edu.cn

科研方向：神经系统疾病、肿瘤、干细胞的细胞外囊泡机制研究、复杂疾病的蛋白质组学研究

中华医学遗传学学会会员，甘肃省生物工程学会理事，甘肃省医学遗传学学会会员，甘肃省健康管理研究会常务理事及干细胞外泌体专业委员会主委，甘肃省创新方法研究会兰州大学分会理事，甘肃省科普专家。SCI、兰州大学学报、生物医学转化等杂志审稿专家。发表SCI论文32篇，联合培养硕士及博士研究生30余名。主持2项甘肃省自然基金，1项兰州市科技计划、3项甘肃省重点实验室开放基金，3项中央高校基本科研费项目，5项横向课题，参加多项国家自然科学基金及国际合作。联合培养硕士及博士研究生40余名。

承担《医用细胞生物学》、《医学遗传学》、《分子医学》、《蛋白质组学》本科课程，《蛋白质组学进展》、《细胞与基因治疗》研究生课程;主持4项校级教学项目，发表教学论文2篇，获2024年隆基教学新秀奖;获兰州大学青年教师讲课比赛优秀奖，基础医学院青年教师授课大赛二等奖。指导3项国家级大学生创新创业项目，2项新医科本科交叉创新训练计划项目，16项校级大学生创新创业项目，指导学生获2项第十届大学生基础医学创新研究暨实验设计论坛三等奖; 2025(省级)、2021、2015年获兰州大学学生创新创业行动计划“优秀指导教师”;2014、2015获得兰州大学暑期科技、文化、卫生“三下乡”社会实践“优秀指导教师”。2021年获欧美同学会第二届“双创”大赛二等奖。

干细胞、免疫细胞的细胞外囊泡治疗

细胞外囊泡在肿瘤微环境中的作用机制

细胞外囊泡的分子诊断

复杂疾病的蛋白质组学研究

主持的科研项目

  1. 甘肃省科学技术厅，中央引导地方项目，25ZYJA018，干细胞外泌体在再生医学领域关键技术的研发及临床应用研究，2025/01-2027/01；参加
  2. 甘肃省科学技术厅，自然科学基金，25JRRA654, iPSC-Exo通过相分离DD3X3炎症反应治疗肺纤维化的机制研究，2025/02 -2028/02；
  3. 兰州市科技计划项目，2023-2-74，iPSC-EXO在再生医学中的转化研究，2023/09-2025/09；
  4. 甘肃省自然科学基金（22JR5RA509），iPSC-MSCs-Exos通过TLR4/NF-κB调节巨噬细胞炎症表型的机制研究，2022/10-2024/09；
  5. 国家卫健委胃肠肿瘤诊治重点实验室开放基金（NLDTG2020005），肿瘤相关巨噬细胞来源外泌体通过功能性14-3-3E转移对胃癌细胞影响的机制研究，2021/01 -2022/12；
  6. 国家自然科学基金面上项目（31870335），黄芩素通过IP3通路调节内质网应激水平干预脑缺血后神经损伤的机制研究，2019/01-2020/12；主持子课题；
  7. 甘肃省生物治疗与再生医学重点实验室开放课题基金项目（zdsyskfkt-201703），肝癌干细胞的差异蛋白质组学研究， 2017/09-2020/09；

 

 

已发表的论文：

  1. Song J, Su G*, Chen W, Xie X, Zhang Z*. M2 macrophage-derived exosomes mitigate acute inflammation following ischemic stroke. Front Neurol. 2026 Feb 4;17:1733679. doi: 10.3389/fneur.2026.1733679
  2. Feng XL#, Su G#, Jia Q, Wu QH, Zhang ZC. B7-H3: a promising target for immunotherapy in glioma. Discov Oncol. 2025 Oct 31;16(1):1998. doi: 10.1007/s12672-025-03328-y
  3. Dong B, Zhang Y, Kang T, Wang F, Su G*. A new perspective for the diagnosis of pancreatic cancer: based on the understanding of extracellular vesicle proteins. Expert Rev Mol Diagn. 2025 Aug 8. doi: 10.1080/14737159.2025.2545968
  4. Feng XL#, Su G#, Wu QH, Jia Q, Zhang ZC. Research progress of galectins in glioma. Discov Oncol. 2025 Jun 4;16(1):1003. doi: 10.1007/s12672-025-02318-4
  5. An Y#, Su G#, Chen W, Song J, Chai M, Zhu L, Zhang Z. Research Progress on the Mechanisms of Microglial Extracellular Vesicles Affecting the Prognosis of Ischemic Stroke. Neurochem Int. 2025 Feb 25:105949. doi: 10.1016/j.neuint.2025.105949
  6. Wu Q, Chen S, Xie X, Yan H, Feng X, Su G*, Zhang Z*. Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway. J Neurooncol. 2025 Feb 28. doi: 10.1007/s11060-024-04934-6
  7. Chen W#, Su G#, Chai M, An Y, Song J, Zhang Z. Astrogliosis and glial scar in ischemic stroke - focused on mechanism and treatment. Exp Neurol. 2025 Mar;385:115131. doi: 10.1016/j.expneurol.2024.115131
  8. Zhu L#, Su G#, Li R, Ma T, Chen W, Song J, Wu Q, An Y, Wang C, Zhang Z. The role of hypoxia/ischemia preconditioning in ischemic stroke. Neuroscience. 2025 Jan 23:S0306-4522(25)00052-1. doi: 10.1016/j.neuroscience.2025.01.042
  9. Gao J#, Su G#, Liu J, Song J, Chen W, Chai M, Xie X, Wang M, Liu J, Zhang Z. A Novel Compound Ligusticum Cycloprolactam Alleviates Neuroinflammation After Ischemic Stroke via the FPR1/NLRP3 Signaling Axis. CNS Neurosci Ther. 2024 Dec;30(12):e70158. doi: 10.1111/cns.70158
  10. Gao J#, Su G#, Liu J, Shen M, Zhang Z, Wang M. Formyl peptide receptors in the microglial activation: New perspectives and therapeutic potential for neuroinflammation. FASEB J. 2024 Nov 15;38(21):e70151. doi: 10.1096/fj.202401927R
  11. Chai M#, Su G#, Chen W, Gao J, Wu Q, Song J, Zhang Z. Effects of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Central Nervous System Diseases. Mol Neurobiol. 2024 Feb 23. doi: 10.1007/s12035-024-04032-8
  12. Ma T#, Su G#, Wu Q, Shen M, Feng X, Zhang Z. Mesenchymal stem cell exosomes: a promising delivery system for glioma therapy. Oncologie. 2024. doi: 10.1515/oncologie-2023-0482
  13. Ma T#, Su G#, Wu Q, Shen M, Feng X, Zhang Z. Tumor-derived extracellular vesicles: how they mediate glioma immunosuppression. Mol Biol Rep. 2024 Jan 28;51(1):235. doi: 10.1007/s11033-023-09196-5
  14. Gao X#, Su G#, Chai M, Shen M, Hu Z, Chen W, Gao J, Li R, Ma T, An Y, Zhang Z. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochem Int. 2024 Jan;172:105656. doi: 10.1016/j.neuint.2023.105656
  15. Zhang J, Shi M, Wang J, Li F, Du C, Su G*, Xie X*, Li S*. Novel Strategies for Angiogenesis in Tissue Injury: Therapeutic Effects of iPSCs-Derived Exosomes. Angiology. 2023 Nov 7:33197231213192. doi: 10.1177/00033197231213192
  16. Liu JF#, Su G#, Chen LX, Zhou JP, Gao J, Zhang JJ, Wu QH, Chen W, Chen DY, Zhang ZC. Irisin Attenuates Apoptosis Following Ischemia-Reperfusion Injury Through Improved Mitochondria Dynamics and ROS Suppression Mediated Through the PI3K/Akt/mTOR Axis. Mol Neurobiol. 2023 Aug;60(8):4261-4272. doi: 10.1007/s12035-023-03336-5
  17. Gao J, Liu J, Li Y, Liu J, Wang H, Chai M, Dong Y, Zhang Z, Su G*, Wang M*. Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke. J Neurosci Res. 2023 Sep;101(9):1393-1408. doi: 10.1002/jnr.25200
  18. Gao J#, Su G#, Chen W, Wu Q, Liu J, Liu J, Chai M, Dong Y, Wang H, Chen L, Zhang Z, Wang M. Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification. Clin Exp Pharmacol Physiol. 2023 Aug;50(8):647-663. doi: 10.1111/1440-1681.13784
  19. Su G, Lei X, Wang Z, Xie W, Wen D, Wu Y. Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders. Curr Mol Med. 2023;23(4):350-357. doi: 10.2174/1566524022666220511123625
  20. Chai M#, Su G#, Gao J, Chen W, Wu Q, Dong Y, Wang H, Chen D, Li Y, Gao X, Li R, Ma T, Zhang Z. Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins. Neurochem Res. 2022 Oct 12. doi: 10.1007/s11064-022-03760-4
  21. Wu Q, Wei H, Meng W, Xie X, Zhang Z*, Su G*. Effect of AnnexinA Group Translocated in Extracellular Vesicles on Tumorigenesis. Curr Mol Med. 2021;21(4):347-353. doi:10.2174/1566524020666200825163512
  22. Zhang J#, Su G#, Wu Q, Liu J, Tian Y, Liu X, Zhou J, Gao J, Chen W, Chen D. Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases. Int J Neurosci. 2021;131(10):1012-1018. doi:10.1080/00207454
  23. Su G, Ma X, Wei H. Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment. Biomed Res Int. 2020 Jul 14;2020: 5608382. doi: 10.1155/2020/5608382
  24. Gao J#, Su G#, Liu J, Zhang J, Zhou J, Liu X, Tian Y, Zhang Z. Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin. J Mol Neurosci. 2020 Aug;70(8):1229-1236. DOI: 10.1007/s12031-020-01531-w
  25. Tian Y#, Su G#, Liu JF, Liu XY, Zhou JP, Chen DY, Zhang ZC. Rodent models for intravascular ischemic cerebral infarction: a review of influencing factors and method optimization. Neuroreport. 2020 Nov 4;31(16):1154-1160. DOI: 10.1097/WNR.0000000000001529
  26. Liu J#, Su G#, Gao J, Tian Y, Liu X, Zhang Z. Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms. Neurochem Res. 2020 Apr; 45(4): 720-730. DOI: 10.1007/s11064-020-02971-x
  27. Zhang J#, Su G#, Lin Y, Meng W, Lai JKL, Qiao L, Li X, Xie X. Targeting cyclin-dependent kinases in gastrointestinal cancer therapy. Discov Med. 2019 Jan;27(146):27-36.
  28. Su G, Yang W, Meng W, Wu Q, Luo Y, Ma X, Zhao S, Xie X, Guo GQ. Anti-proliferation effects of ethanolic extracts from Sophora moorcroftiana seeds on human hepatocarcinoma HepG2 cell line. Nat Prod Res. 2018 Jun;32(12):1472-1475. doi: 10.1080/14786419.2017.1353503
  29. Zhang J#, Su G#, Tang Z, Wang L, Fu W, Zhao S, Ba Y, Bai B, Yue P, Lin Y, Bai Z, Hu J, Meng W, Qiao L, Li X, Xie X. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018 Mar 20;9:234. DOI: 10.3389/fphys.2018.00234
  30. Zhao S#, Su G#, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X. Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. Technol Cancer Res Treat. 2017 Dec;16(6):1092-1101. DOI: 10.1177/1533034617732426
  31. Zhao LL#, Su G#, Chen LX, Yan Q, Wang XP, Yuan W, Wang L, Zhang ZC. Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population. Biosci Rep. 2017 Nov 29;37(6):BSR20171088. DOI: 10.1042/BSR20171088
  32. Zhang Z, Yan Q, Guo J, Wang X, Yuan W, Wang L, Chen L, Su G*, Wang M*. A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype. Sci Rep. 2017 Oct 17;7(1):13390. DOI: 10.1038/s41598-017-13542-6
  33. 苏刚,张雪燕,李培强,郝春燕,李炯,程菊,景玉宏.医学整合课程——《分子医学》的建设和实践[J].中华医学教育探索杂志,2024,23(2):250-255
  34. 苏刚, 李炯, 吴骅, 李培强, 谢小冬.医学遗传学线上线下混合教学模式改革[J]. 生物工程学报, 2021, 37(8):9

学院地址: 甘肃省兰州市东岗西路199号 兰州大学基础医学院 邮编: 730000

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学术不端和师德师风问题举报电话：0931-8915092　举报邮箱：jcyxy@lzu.edu.cn