神经系统疾病中细胞外囊泡在小胶质细胞极化中的作用机制研究

细胞外囊泡在肿瘤微环境中的作用机制研究

细胞外囊泡在复杂疾病中的治疗作用

复杂疾病、细胞外囊泡的蛋白质组学研究

主持项目：

1. 甘肃省自然科学基金（22JR5RA509），iPSC-MSCs-Exos通过TLR4/NF-κB调节巨噬细胞炎症表型的机制研究，2022/10-2024/09；
2. 国家卫健委胃肠肿瘤诊治重点实验室开放基金（NLDTG2020005），肿瘤相关巨噬细胞来源外泌体通过功能性14-3-3E转移对胃癌细胞影响的机制研究，2021/01 -2022/12；
3. 国家自然科学基金面上项目（31870335），黄芩素通过IP3通路调节内质网应激水平干预脑缺血后神经损伤的机制研究，2019/01-2020/12；主持子课题；
4. 甘肃省生物治疗与再生医学重点实验室开放课题基金项目（zdsyskfkt-201703），肝癌干细胞的差异蛋白质组学研究， 2017/09-2020/09；
5. 兰州大学中央高校基本科研费自由探索项目（lzujbky-2016-63），短管兔耳草总黄酮对PC12细胞损伤模型的蛋白质组学研究，2016/01-2017/06；
6. 兰州大学中央高校基本科研费自由探索项目（lzujbky-2013-222），非小细胞肺癌化疗的差异蛋白质组学研究，2013/01-2014/06；

研究成果：

1. Chai M^#, Su G^#, Chen W, Gao J, Wu Q, Song J, Zhang Z. Effects of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Central Nervous System Diseases. Mol Neurobiol. 2024 Feb 23. doi: 10.1007/s12035-024-04032-8
2. Ma T^#, Su G^#, Wu Q, Shen M, Feng X, Zhang Z. Mesenchymal stem cell exosomes: a promising delivery system for glioma therapy. Oncologie. 2024. https://doi.org/10.1515/oncologie-2023-0482
3. Ma T^#, Su G^#, Wu Q, Shen M, Feng X, Zhang Z. Tumor-derived extracellular vesicles: how they mediate glioma immunosuppression. Mol Biol Rep. 2024 Jan 28;51(1):235. doi: 10.1007/s11033-023-09196-5
4. Gao X^#, Su G^#, Chai M, Shen M, Hu Z, Chen W, Gao J, Li R, Ma T, An Y, Zhang Z. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochem Int. 2024 Jan;172:105656. doi: 10.1016/j.neuint.2023.105656
5. Zhang J, Shi M, Wang J, Li F, Du C, Su G*, Xie X*, Li S*. Novel Strategies for Angiogenesis in Tissue Injury: Therapeutic Effects of iPSCs-Derived Exosomes. Angiology. 2023 Nov 7:33197231213192. doi: 10.1177/00033197231213192
6. Liu JF^#, Su G^#, Chen LX, Zhou JP, Gao J, Zhang JJ, Wu QH, Chen W, Chen DY, Zhang ZC. Irisin Attenuates Apoptosis Following Ischemia-Reperfusion Injury Through Improved Mitochondria Dynamics and ROS Suppression Mediated Through the PI3K/Akt/mTOR Axis. Mol Neurobiol. 2023 Aug;60(8):4261-4272. doi: 10.1007/s12035-023-03336-5
7. Gao J, Liu J, Li Y, Liu J, Wang H, Chai M, Dong Y, Zhang Z, Su G*, Wang M*. Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke. J Neurosci Res. 2023 Sep;101(9):1393-1408. doi: 10.1002/jnr.25200
8. Gao J^#, Su G^#, Chen W, Wu Q, Liu J, Liu J, Chai M, Dong Y, Wang H, Chen L, Zhang Z, Wang M. Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification. Clin Exp Pharmacol Physiol. 2023 Aug;50(8):647-663. doi: 10.1111/1440-1681.13784
9. Su G, Lei X, Wang Z, Xie W, Wen D, Wu Y. Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders. Curr Mol Med. 2023;23(4):350-357. doi: 10.2174/1566524022666220511123625
10. Chai M^#, Su G^#, Gao J, Chen W, Wu Q, Dong Y, Wang H, Chen D, Li Y, Gao X, Li R, Ma T, Zhang Z. Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins. Neurochem Res. 2022 Oct 12. doi: 10.1007/s11064-022-03760-4
11. Wu Q, Wei H, Meng W, Xie X, Zhang Z*, Su G*. Effect of AnnexinA Group Translocated in Extracellular Vesicles on Tumorigenesis. Curr Mol Med. 2021;21(4):347-353. doi:10.2174/1566524020666200825163512
12. Zhang J^#, Su G^#, Wu Q, Liu J, Tian Y, Liu X, Zhou J, Gao J, Chen W, Chen D. Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases. Int J Neurosci. 2021;131(10):1012-1018. doi:10.1080/00207454
13. Su G, Ma X, Wei H. Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment. Biomed Res Int. 2020 Jul 14;2020: 5608382. doi: 10.1155/2020/5608382
14. Gao J^#, Su G^#, Liu J, Zhang J, Zhou J, Liu X, Tian Y, Zhang Z. Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin. J Mol Neurosci. 2020 Aug;70(8):1229-1236. DOI: 10.1007/s12031-020-01531-w
15. Tian Y^#, Su G^#, Liu JF, Liu XY, Zhou JP, Chen DY, Zhang ZC. Rodent models for intravascular ischemic cerebral infarction: a review of influencing factors and method optimization. Neuroreport. 2020 Nov 4;31(16):1154-1160. DOI: 10.1097/WNR.0000000000001529
16. Liu J^#, Su G^#, Gao J, Tian Y, Liu X, Zhang Z. Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms. Neurochem Res. 2020 Apr; 45(4): 720-730. DOI: 10.1007/s11064-020-02971-x
17. Zhang J^#, Su G^#, Lin Y, Meng W, Lai JKL, Qiao L, Li X, Xie X. Targeting cyclin-dependent kinases in gastrointestinal cancer therapy. Discov Med. 2019 Jan;27(146):27-36.
18. Su G, Yang W, Meng W, Wu Q, Luo Y, Ma X, Zhao S, Xie X, Guo GQ. Anti-proliferation effects of ethanolic extracts from Sophora moorcroftiana seeds on human hepatocarcinoma HepG2 cell line. Nat Prod Res. 2018 Jun;32(12):1472-1475. doi: 10.1080/14786419.2017.1353503
19. Zhang J^#, Su G^#, Tang Z, Wang L, Fu W, Zhao S, Ba Y, Bai B, Yue P, Lin Y, Bai Z, Hu J, Meng W, Qiao L, Li X, Xie X. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018 Mar 20;9:234. DOI: 10.3389/fphys.2018.00234
20. Zhao S^#, Su G^#, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X. Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. Technol Cancer Res Treat. 2017 Dec;16(6):1092-1101. DOI: 10.1177/1533034617732426
21. Zhao LL^#, Su G^#, Chen LX, Yan Q, Wang XP, Yuan W, Wang L, Zhang ZC. Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population. Biosci Rep. 2017 Nov 29;37(6):BSR20171088. DOI: 10.1042/BSR20171088
22. Zhang Z, Su G, Guo J, Li J, Wu H, Wang M, Xie X. Pooled genetic analysis reveals an association of SNPs of only a few genes with risk predisposition to ischemic stroke in a Chinese population. IUBMB Life. 2015 Mar;67(3):170-4.
23. Zhang ZC, Su G, Li J, Wu H, Xie XD. Two new neuroprotective phenolic compounds from Gastrodia elata. J Asian Nat Prod Res. 2013;15(6):619-23.
24. 苏刚,张雪燕,李培强,郝春燕,李炯,程菊,景玉宏.医学整合课程——《分子医学》的建设和实践[J].中华医学教育探索杂志,2024,23(2):250-255
25. 苏刚, 李炯, 吴骅, 李培强, 谢小冬.医学遗传学线上线下混合教学模式改革[J]. 生物工程学报, 2021, 37(8):9.