研究领域：

（1） 肺纤维化的发病机制与干预

（2） EBV相关肿瘤发病机制与免疫治疗

Research Interest

1. Pathogenesis and therapy of pulmonary fibrosis (PF).

2. Pathogenesis and immune therapy of EBV-associated cancer.

研究成果

项目主持

1. 国家自然科学基金面上项目（32070150），BZLF1-Pax5轴去分化EBV+B细胞的分子机制研究，2020.1-2024.12，主持。
2. 国家自然科学基金面上项目（8170044），PINK1-Parkin信号通路调控的线粒体自噬在CSE所致肺损伤中的作用和机制，2018.1-2021.12，第二参与者。
3. 甘肃省卫健委中医药研究项目（GZKP-2023-37），黄芪总黄酮对肺纤维化合并肺癌中肺纤维化治疗效果和机制研究，2024.1-2026.12，主持。
4. 甘肃省自然基金面上项目（22JR5RA497），特发性肺纤维化伴发肺癌的发病机制与干预治疗，2022.10-2024.09，主持。
5. 甘肃省自然基金面上项目（18JR3RA279），Tenascin C 通过激活Toll样受体介导的先天免疫应答调控肺纤维化的机制，2018.7-2020.6，主持。
6. 中央高校基本科研业务费专项资金自由探索项目(lzujbky-2017-18)，Toll样受体4介导的先天免疫应答调控肺纤维化的分子机制研究，2017.1-2018.12，主持。
7. 兰州大学“萃英人才建设计划”引进人才专项基金，2016.3-2017.12，主持。

科研成果

1. Yixiang Wang, Fanghan Xue, Wei Chen, Qian Zhao, Nazi Song, Zihan Shi, Han Liu, Yu Li, Qinglin Tang, Qi Liu, Yiqing Wang, Fangfang Zhang, Xianxing Jiang, Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment, Journal of Medicinal Chemistry, 2024, 67 (8):6624-6637. (SCI一区，通讯作者)

2. Chenguang Yang, Xueli Mao, Junfei Wu, Xiang An, Jiajia Cao, Xiaoyu Zhang, Min Li, Fangfang Zhang, Amelioration of Lung fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration, The American Journal of Chinese Medicine, 2023, 51 (2): 373-389.（SCI 二区，通讯作者）

3. Yanling Jin, Wei Cai, Chanyuan Zhao, Feng Yang, Chenguang Yang, Xiaoyu Zhang, Quan Zhou, Wenjie Zhao, Chenli Zhang, Fangfang Zhang, Min Wang, Min Li*, EMT status of circulating breast cancer cells and impact of fluidic shear stress, Experimental cell research, 2022, 421,113385. （通讯作者）

4. Yanling Jin, Wei Liu, Fengxia Wang, Min Wang, Kai Xu, Aijun Yang, Chenyu Wang, Lihan Zhang, Fangfang Zhang, Min Li, Tissue Factor Potentiates Adherence of Breast Cancer Cells to Human Umbilical Vein Endothelial Cells under Static and Flow Conditions, Cell Adhesion & Migration 2021, 15(1):74-83. (SCI 二区，通讯作者)

5. Wencheng Wu, Chenyu Wang, Fengxia Wang, Yan Wang, Yanling Jin, Jing Luo, Min Wang, Chenli Zhang, Shuya Wang, Fangfang Zhang, Min Li, Silencing the COPB2 Gene Decreases Proliferation, Migration and Invasion of Human Triple-Negative Breast Cancer Cells, Experimental and Therapeutic Medicine, 2021,  22(792):1-8. (通讯作者)

6. Jing Wei, Chen Guo, Xiang An, Wenxuan Miao, Chenli Zhang, Binsheng Wang, Wei Cai, Min Li, Fangfang Zhang, Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer, Cellular Oncology, 2020, 43:1085-1097. (SCI二区, 通讯作者)

7. Chen Guo, Jing Wei, Rona S. Scott, Yonglin Chen, Zhifeng Chen, Wenjie Zhao, Chenli Zhang, Binsheng Wang, Chen Chai, Gan Dai, Min Li, Fangfang Zhang, Prevalence and characteristics of Epstein-Barr virus associated gastric carcinoma in Gansu Province, Northwest China with mRNA expression of glycoprotein BMRF2, Journal of Medical Virology, 2020, 92(3): 356-363. (通讯作者)

8. Xiao Zhang, Chenli Zhang, Zhiheng Ren, Fangfang Zhang, Jinyu Xu, Xu Zhang, Haixue Zheng, Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin, Cancer Management and Research, 2020, 12: 3795-3806.

9. 毛雪丽，张娜，赵鹏飞，张丽，刘子豪，卢锦辉，侯皓中，张芳芳，细胞因子对肺纤维化的影响及机制研究进展，临床肺科杂志，2020，25（5）：778-781，（中文核心，通讯作者）.

10. Guangliang Liu, Fangfang Zhang, Ruixue Wang, Steven D. London, Lucille London, Salivary gland immunization via Wharton's duct activates differential T-cell responses within the salivary gland immune system, The FASEB Journal 2019, 33(5): 6011-60. (SCI二区, IF=4.966).

11. 卢锦辉，张丽，刘子豪，毛雪丽，张娜，周全，罗晶，武雯程，李敏，张芳芳，博来霉素诱导小鼠肺纤维化模型的建立及评价，兰州大学学报（医学版），2019，45（6）：37-42，(中文核心，通讯作者）.

12. Zhiheng Ren, Chenli Zhang, Linna Ma, Xiao Zhang, Shuxia Shi, Deng Tang, Jinyu Xu, Yan Hu, Binsheng Wang, Fangfang Zhang, Xu Zhang, Haixue Zheng, Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways, International Journal of Molecular Medicine, 2018, 44 (1):67-78.

13.Guangliang Liu , Fangfang Zhang, Ruixue Wang, Lucille London, Steve D. London*, Protective MCMV immunity by vaccination of the salivary gland via Wharton's duct: replication-deficient recombinant adenovirus expressing individual MCMV genes elicits protection similar to that of MCMV, The FASEB Journal, 2014, 28(4): 1698-1710.

14.Guangliang Liu, Fangfang Zhang, Jianzhong Shi, Guobing. Tian, Hualan Chen, Kangzhen Yu, and Qinwen Meng, A Subunit Vaccine Candidate Derived from a Classic H5N1 Avian Influenza Virus in China Protects Fowls and BALB/c Mice from Lethal Challenge, Vaccine, 2013, 31 (46): 5398-5404.

15.Fangfang Zhang, Yan Zeng, Chunwang Li, Aichun Xu and Zhigang Jiang, Ecological environment and migratory behavior affect the phylogeography and demography of chiru and Tibetan gazelle on Tibetan Plateau. PLoS ONE. 2013, 8 (4): e60712.

16.Sreedevi Avasarala*, Fangfang Zhang*, Guangliang Liu, Ruixue Wang, Steve D. London, and Lucille London, Curcumin Modulates the Inflammatory Response and Inhibits Subsequent Fibrosis in a Model of Viral-induced Acute Respiratory Distress Syndrome. PloS ONE. 2013, 8 (2): e57285. (* Co-first author).

17.Krista J. Queen, Minxia Shi, Fangfang Zhang, Urska Cvek and Rona S. Scott, Epstein-Barr Induced Epigenetic Alterations Following Transient Infection. International Journal of Cancer. 2012, 132: 2076-2086.

18.Kazufumi Ikuta, Minyu Ding, Fangfang Zhang, John W. Sixbey and Rona S. Scott, Epithelial cell retention of transcriptionally active, P3HR-1-Derived heterogeneous (het) EBV DNA with concurrent loss of parental virus. Journal of Virology. 2011, 85 (15): 7634-7643.

19.Yan Luo, Hongyu Zhou, Lei Liu, Tao Shen, Wenxin Chen, Baoshan Xu, Xiuzhen Han, Fangfang Zhang, Rona S. Scott, J Steven Alexander, Antoine Alam and Shile Huang, The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene. 2010:1-10.

20.Fangfang Zhang, Zhigang Jiang, Yan Zeng, Tim McCarthy, Developement of primers to characterize the mitochondrial control region of snow leopard (uncia uncia). Molecular Ecology Notes. 2007, 7(6): 1196-1198.

21.Fangfang Zhang, Zhigang Jiang, Mitochondrial phylogeography and genetic diversity of Tibetan gazelle (Procapra picticaudata): Implicatons for conservation. Molecular Phylogenetics and Evolution. 2006, 41: 313-321.

22.Fangfang Zhang, Yongping Jiang, Guangliang Liu, Huaitao Chen, Chuanling Qiao, Hualan Chen, The Immunogenicity of DNA vaccine co-expressing HA gene of H5 and H7 subtype of AIV. Chinese Journal of Preventing Veterinary Medicine. 2006, 28:1-5. (In Chinese)

23.Yongping Jiang, Hongbo Zhang, Chengjun Li, Zhigao Bu, Fangfang Zhang, Kangzhen Yu, Hualan Chen, Increased expression and immunogenicity of optimized H5 subtype avian influenza HA gene containing chicken bias codons. Immunological Journal. 2005, 21:377-381. (In Chinese)

24.Yongping Jiang, Chengjun Li, Hongbo Zhang, Zhigao Bu, Fangfang Zhang, Guohua Deng, Kangzhen Yu, Hualan Chen. Construction of codon optimized H5 avian influenza HA gene with chicken bias codons and in vitro expression of its DNA vaccine. Chinese Journal of Preventing Veterinary Medicine. 2005, 27: 441-444. (In Chinese)

25.Fangfang Zhang, Guangliang Liu, Yongping Jiang, Huaitao Chen, Hualan Chen. Construction and co-expression in vitro of DNA vaccine which expressing HA gene of AIV H5 and H7 subtype. Progress in Veterinary Medicine. 2004, 25:107-110. (In Chinese)

26.Fangfang Zhang, Guangliang Liu, Yongping Jiang, Hualan Chen and Huaitao Chen. The Strategies of improving Immunogenicity of DNA Vaccine. Progress in Veterinary Medicine. 2004, 5: 41-43. (In Chinese)