1.抗肿瘤活性多肽药物的作用靶点确认及机制研究

2.多肽靶向的放射性诊疗药物开发

研究项目（主持）

1. 国家自然科学青年基金项目，批准号：21807053，2019.01-2021.12.

2. 兰州大学引进人才启动经费，2018.01-2020.12。

3. 中央高校基本科研业务费专项资金自由探索项目1项，lzujbky-2018-91，2018.01-2019.12。

4. 中央高校基本科研业务费专项资金重点研究基地，开放课题1项，lzujbky-2018-kb11，2018.01-2020.12。

研究成果

1. H. Yang^#, X. Zhang^#, Cong Wang^#, H. Zhang^# *, J. Yi, K. Wang, Y. Hou1, P. Ji, X. Jin, C. Li, M. Zhang, S. Huang, H. Jia, K. Hu, L. Mou *, R. Wang *. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Sig Transduct Target Ther. 2023, 8, 428. (IF 40.8)。
2. K. Wang^#, C. Wang^#, H. Yang^#, G. Chen^#, K. Wang, P. Ji, X. Sun, X. Fan, J. Ma, L. Wang, J. Yi*, K. Hu*, H. Zhang*, Rui Wang*. A dual targeting peptide-drug conjugate based on CXCR4 and FOLR1 inhibits triple-negative breast cancer. Acta Pharm. Sin. B, 2024, under revision. (IF 14.7)。
3. Juan. Yi^#, H-L. Wang^#, G. Lu^#, H. Zhang, L. Wang, Z-Y. Li, L. Wang, Y. Wu, D. Xia, E. F. Fang, H-M. Shen*. Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model. Autophagy, 2024, doi.org/10.1080/15548627.2024.2383145. (IF 14.6).
4. S. Zhang, X. Ma, J. Wu, J. Shen, Y. Shi, X. Wang, L. Xie, X. Sun, Y. Wu, H. Tian, X. Gao, X. Chen, H. Huang, L. Chen, X. Song, Q. Hu, H. Zhang, F. Wang*, Z-H Jin*, M-R Zhang*, R. Wang*, K. Hu*. Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance. Acta Pharm. Sin. B, 2024 https://doi.org/10.1016/j.apsb.2024.07.006. (IF 14.7)。
5. L. Zhang, S. Zhang, J. Wu, Y. Wang, Y. Wu, X. Sun; X. Wang, J. Shen, L. Xie, Y. Zhang, H. Zhang, K. Hu*, F. Wang*, R. Wang*, M-R. Zhang*. Linear Peptide-Based PET Tracers for Imaging PD-L1 in Tumors. Mol. Pharm. 2023, 20, 4256–4267.(IF 4.5)。
6. H. Zhang, L. Hong, H. Kang, R. Wang *; Construction of vicinal all carbon quaternary stereocenters by catalytic asymmetric alkylation reaction of 3-bromooxindoles with 3-substituted indoles: total synthesis of (+)- Perophoramidine, J. Am. Chem. Soc, 2013, 135, 14098-14101.(IF 14.4)。
7. L. Bai, L. Wang, H. Zhu, S. Pang, S. Li, J. Lv, H. Zhang*, and D. Yang*; Development of prophenol/ti(iv) catalyst for asymmetric hydroxylative dearomatization of naphthols. Org. Lett, 2023, 16, 2394-2397.(IF 4.9)。
8. L. Wang, H. Zhu, T. Peng, Y. Xu, Y. Hou, S. Li, S. Pang, H. Zhang*, and D. Yang*； A tandem asymmetric oxidation-oxa-Michael sequence for dearomatization of βnapht. Chinese Chemical Letters. 2022, 25, 867–871.(IF 9.4)。
9. H. Zhang, H. Kang, L. Hong, and R. Wang*, Org. Lett. 2014, 16, 2394-2397. 
10. H. Zhang, X. Ma, H. Kang, L. Hong, and R. Wang*, Chem. Asian J. 2013, 8, 542-545.