生物活性肽与微生物感染治疗

主持科研项目：

1. 兰州大学中央高校基本科研业务费定向探索项目-优秀研究生创新项目，基于提高天然抗菌肽CPF-C1成药性的双策略修饰改造及活性机制研究，lzujbky-2024-it24，2024.07.01-2026.06.30.

参与发表论文：

1. Tiantian Yan¹, Jingyue Li¹, Yiping Li, Bingzi Ma, Ruoyan Jiao, Xinyu Cai, Xiaoyu Liu, Weili Yang, Wei Dai, Haiya Bai, Wenle Yang, Xiaokang Miao, Junpeng Ran, Guangjun Bao, Junqiu Xie, Wangsheng Sun, Rui Wang. Post-modification of daptomycin at tryptophan enables the discovery of aryl-daptomycin anti-biofilm activity against MRSA. Journal of Medicinal Chemistry. 2026;69(11):13504-13527.

2. Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Fang Li, Weili Yang, Wei Dai, Haiya Bai, Wenle Yang, Xiaokang Miao, Guangjun Bao, Wangsheng Sun, Junqiu Xie, Rui Wang. Rational two-round modification for developing isopeptide bond-containing antimicrobial peptide with enhanced stability and potent activity against multidrug-resistant gram-negative bacteria. Biochemical Pharmacology. 2025;242(Pt 4):117436.

3. Xiaomin Guo, Tiantian Yan, Jing Rao, Yingying An, Xin Yue, Xiaokang Miao, Rui Wang, Wangsheng Sun, Jianfeng Cai, Junqiu Xie. Novel Feleucin-K3-derived peptides modified with sulfono-γ-AA building blocks targeting Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus infections. Journal of Medicinal Chemistry. 2023;66(2):1254-1272.

4. Xiaomin Guo, Tiantian Yan, Jing Rao, Xin Yue, Xiong Pei, Jiahui Deng, Wangsheng Sun, Wenle Yang, Bangzhi Zhang, Junqiu Xie. Potent antimicrobial and antibiofilm activities of Feleucin-K3 analogs modified by α-(4-Pentenyl)-Ala against multidrug-resistant bacteria. Biomolecules. 2021;11(5):761.

5. Xiaomin Guo, Yingying An, Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Weili Yang, Guangjun Bao, Wangsheng Sun, Wenle Yang, Ningning Lu, Junqiu Xie. Halogenated sulfono-γ-AApeptides modified cationic AMPs have enhanced stability and therapeutic potential against clinically important MDR infections. ACS Infectious Diseases. 2025;11(7):2018-2036.

6. Xiaomin Guo¹, Xiaokang Miao¹, Yingying An, Tiantian Yan, Yue Jia, Bochuan Deng, Jianfeng Cai, Wenle Yang, Wangsheng Sun, Rui Wang, Junqiu Xie. Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections. European Journal of Medicinal Chemistry. 2024;264:116001.

7. Yingying An, Xiaomin Guo, Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Bochuan Deng, Guangjun Bao, Yiping Li, Wenle Yang, Rui Wang, Wangsheng Sun, Junqiu Xie. Enhancing the stability and therapeutic potential of the antimicrobial peptide Feleucin-K3 against multidrug-resistant A. baumannii through rational utilization of a D-amino acid substitution strategy. Biochemical Pharmacology. 2024;225:116269.

8. Xiaomin Guo, Jing Rao, Tiantian Yan, Bangzhi Zhang, Wenle Yang, Wangsheng Sun, Junqiu Xie. Feleucin-K3 analogue with an α-(4-Pentenyl)-Ala substitution at the key site has more potent antimicrobial and antibiofilm activities in Vitro and in Vivo. ACS Infectious Diseases. 2021;7(1):64-78.

9. Junqiu Xie, Yao Li, Xiaomin Guo, Jing Rao, Tiantian Yan, Lingyun Mou, Xueping Wu, Xinxin Xie, Wenle Yang, Bangzhi Zhang. CPF-C1 analog with effective antimicrobial and antibiofilm activities against Staphylococcus aureus including MRSA. Biochimie. 2020;176:1-11.

10. Lu Cheng, Dan Wang, Bochuan Deng, Jieru Li, Jiao Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Junqiu Xie. DR7dA, a novel antioxidant peptide analog, demonstrates antifibrotic activity in pulmonary Fibrosis in vivo and in vitro. Journal of Pharmacology and Experimental Therapeutics. 2022;382(2):100-112.

11. Bochuan Deng, Ping Su, Lu Cheng, Jiao Zhang, Xiang Zhang, Tingli Yu, Guangjun Bao, Tiantian Yan, Yue Yin, Lei Shen, Dan Wang, Liang Hong, Xiaokang Miao, Wenle Yang, Chenyu Wang, Junqiu Xie, Rui Wang. Iterative optimization yields stapled peptides with superior pharmacokinetics and potency for renal fibrosis treatment. Journal of Medicinal Chemistry. 2025;68(8):8516-8529.

12. Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Jiao Zhang, Xiang Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Wenle Yang, Junqiu Xie, Rui Wang. A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis. Acta Pharmaceutica Sinica B. 2023;13(2):722-738.

授权专利：

1. 谢俊秋；王锐；闫甜甜. 基于蛙源抗菌肽CPF-C1的衍生肽及其制备方法和应用. 2025-11-04. 中国. 发明专利. CN 119591671 B.