1、采用规范的细胞和分子生物学/生理学技术进行有关生理、药理学方面的研究。

2、采用细胞信号转导、氧化胁迫以及细胞凋亡技术对心血管疾病、糖尿病以及肥胖等进行研究。

主持的科研项目：

1. 主持甘肃省省自然科学研究基金计划项目一项(1208RJZA231)，异甘草素抗肿瘤血管生成的机制研究，2012.1-2014.12

2. 主持甘肃省省自然科学研究基金计划项目一项(0710RJZA037)，稀土配合物抗肿瘤作用分子机理研究，2008.1-2009.12

3. 主持兰州市科技计划资助项目一项(1208RJZA231)异甘草素抗肿瘤血管生成的机制研究，2007.1-2008.12

4. 主持企事业单位委托项目，戊肝疫苗临床前重复给药，毒性试验，2005.11-2007.6

5. 主持企事业单位委托项目，蛇葡萄素抗肿瘤作用的研究，2006.4-2007.12

6. 主持兰州大学医学基金一项，稀土配合物抗肿瘤作用及机理研究，2007.1-2008.12

7. 主持甘肃省新药临床前研究重点实验室开放课题基金一项，二(2-吡啶基-N-氧化物)二硫化物镧稀土配合物的抗肿瘤作用及机理研究，2006.1-2008.12

参与科研项目情况：

1. 以项目组主要成员(2/9)参与国家自然科学基金委——面上项目一项，填充吸附微量萃取法结合细胞代谢组学研究金纳米材料的毒性，2014.1-2017.12

2. 以项目组主要成员(2/4)参与甘肃省自然基金项目一项，抗病毒药筛选模型的建立及抗病毒中药，2004.7-2006.12

发表论文

1. Xiaoyu Zhang, Ping Zhu, Xiuying Zhang, Yina Ma, Wenguang Li, Ji-Mei Chen,Hui-Ming Guo, Richard Bucala, Jian Zhuang, and Ji Li. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation. Volume 2013, Article ID 390890, 10 pages.(SCI, IF2013 = 3.882)

2. XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247–1257. (SCI)

3. XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309–318. (SCI)

4. XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043–1052. (SCI)

5. Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533–538. (SCI)

6. XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432–438. (SCI)

7. Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract) (SCI)

8. Xiaoyu Zhang, Eddie D Yeung, Jingying Wang, Evgeniy E Panzhinskiy, Tong Chao, Wenguang Li, Ji Li. Natural antioxidant-Isoliquiritigenin selectively inhibits growth of prostate cancer cells. Clin. Exp. Physiol. Pharm. 2010; 37: 841–847 (SCI)

9. WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941–949. (SCI)

10. LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727–732. (SCI)

11. LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI)

12. ZHANG XiaoYu, ZHENG TianZhen and PANG JinJiang. Effects of progesterone on contractile activity of trachea smooth muscle in rabbits. Chin J Appl Physiol. 2003; 19(4): 388, 401. (CSCD)

13. ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Wei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD)

14. ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16 (CSCD)

15. ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120.

16. ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J Lanzhou University ( Natural Sci). 2004; 40Supp: 34–36. (CSCD)

17. ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. (CSCD)

18. Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract)

19. Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008;60(2): 179-188. (SCI)

20. Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang*, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, Rui Wang* .Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behav Brain Res. 2013; 248; 51-56. (SCI)

21. SI JinChao, ZHANG XiaoYu, LIN MeiLing, DING YongHui, LI Mei, QU SongYi and ZHENG TianZhen. Effects of Ephedra on body mass, serum lipid, glucose and hormone level of ovarietomized obese rats. Chin J Clin Rehabilit. 2006; 10(47): 209–212. (CSCD)

22. LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. (CSCD)

23. Jingying Wang, Heng Ma, Xiaoyu Zhang, Leilei He, Jianming Wu, Xiaoping Gao, Jun Ren, Ji Li. A Novel AMPK Activator from Chinese Herb Medicine and Ischemia Phosphorylate the Cardiac Transcription Factor FOXO3. Int J Physiol Pathophysiol Physiol. 2009: 1: 116-126 (SCI)

24. Peng Zhao, Jingying Wang, Leilei He, Heng M, Xiaoyu Zhang, Xinglei Zhu, E. Kurt Dolence, Jun Ren, Ji Li. Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia. J. Cell. Mol. Med. 2009; 13: 1513–1525 (SCI)

25. Wang Jun, Wang Hao, Guo Zhen, ZHANG XiaoYu, QU SongYi and ZHENG TianZhen. Gastrodin in modulating body mass and metabilism in obese rats fed with high-fat diet. J Clin Rehabilit. Tissue Engineering Res. 2008; 12(207): 3992–3996. (CSCD)

26. Guo Jiaohong, Li Xujun, Yue Jia, ZHANG XiaoYu, Lin Meiling and ZHENG TianZhen. The effects of Radix Achykanthis Bidentatae from Henan of China on body weight and tumor Necrosis Factor-α in ovariectomized obese rats. J Chengdu Medical College 2008; 3(2): 100–102, 106.

27. Li Xujun, Yue Jia, Chang Yanqin, Lin Meiling, ZHANG XiaoYu, Ding Yonghui and ZHENG TianZhen. Effects of Rhizoma Wenyujin Concisum on ovariectomized obese rats. China J Modern Med. 2008; 18(4): 405–407, 412. (CSCD)

28. 袁良杰，卢霞，王君，郑天珍，瞿颂义，张小郁*. 苦参碱对高脂肥胖大鼠体重、血脂和抗过氧化能力的影响. 时珍国医国药. 2008; 19(9): 2062-2064(*为通讯作者)(CSCD)

29. 白 岩，卢伍党，李文广，张小郁*. 金属配合物Cu(Ⅱ)1-羟基-3-(2-环氧基)吨酮的体外抗肿瘤作用. 兰州大学学报(医学版). 2010; 36(2): 56-60 (*为通讯作者)

30. 白 岩，卢伍党，李文广，张小郁*. 金属配合物Cu(Ⅱ)吨酮冠醚的体外抗肿瘤作用. 兰州大学学报(医学版). 2010; 36(3): 21-25(*为通讯作者)

31. 黄征，张林，瞿颂义， 郑天珍，张小郁*. 天麻素对大鼠离体脂肪组织释放游离脂肪酸及抗氧化作用的影响. 第四军医大学学报(J. Fourth Mil. Univ.). 2009：30(16)：1488-1490. (*为通讯作者)(CSCD)

32. 朱家恩，白延斌，蔺美玲，郑天珍，瞿颂义，丁永辉，张小郁*.白芍对去卵巢大鼠体重、血脂及抗氧化能力的影响.中国老年学杂志，2009, 29(2): 135-137 (*为通讯作者)(CSCD)

33. 赵丽，陈红梅，蔺美玲，刘世雄，李中平，王志强，张小郁*，郑天珍.原花青素对STZ致胰岛细胞损伤的保护作用. 中国老年学杂志，2011, 31(23): 4580-4582 (*为通讯作者)(CSCD)

34. 李中平，任文辉，张宝丽，蔺美玲，陈红梅，赵丽，王志强，张小郁*.槟榔碱对STZ致INS-1细胞损伤的保护和修复作用. 中国老年学杂志，2011, 31(23): 4583-4585 (*为通讯作者)(CSCD)

35. 王志强，黄双盛，刘圆圆，胡腊梅，李文广，侯翠兰, 张小郁*。异甘草素的抗肿瘤血管生成作用.中国科技论文在线, 2012(*为通讯作者)