1.结核亚单位疫苗研究。和兰州生物制品研究所有限责任公司合作研究可提高成人抗结核免疫保护力的亚单位疫苗。

2.结核疫苗诱导的免疫记忆及调节、结核病免疫耗竭机制及干预措施。

3.肿瘤代谢与免疫治疗。

先后主持和国家863计划1项、国家自然科学基金2项、国家科技重大专项子课题及任务5项。

代表性文章：

1.Xun Liu#, Fei Li#, Hongxia Niu, Lan Ma, Jianzhu Chen, Ying Zhang, Liang Peng, Chao Gan, Xingming Ma, Bingdong Zhu*. IL-2 restores T-cell dysfunction induced by persistent Mycobacterium tuberculosis antigen stimulation. Front. Immunol. 2019;10:2350 | https://doi.org/10.3389/fimmu.2019.02350

2.Li F, Liu X, Niu H, Lv W, Han X, Zhang Y, Zhu B*. Persistent stimulation with Mycobacterium tuberculosis antigen impairs the proliferation and transcriptional program of hematopoietic cells in bone marrow. Mol Immunol. 2019 Aug;112:115-122. doi: 10.1016/j.molimm.2019.05.001.

3.Bai C, He J, Niu H, Hu L, Luo Y, Liu X, Peng L, Zhu B*. Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells. Tuberculosis (Edinb). 2018 May;110:104-111. doi: 10.1016/j.tube.2018.04.006. Epub 2018 Apr 24. PubMed PMID: 29779765.

4.Zhu B*, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y. Tuberculosis vaccines: Opportunities and challenges. Respirology. 2018 Apr;23(4):359-368. doi:10.1111/resp.13245. Epub 2018 Jan 17. Review. PubMed PMID: 29341430.

5.Liu X, Peng J, Hu L, Luo Y, Niu H, Bai C, Wang Q, Li F, Yu H, Wang B, Chen H, Guo M, Zhu B*. A multistage Mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Hum Vaccin Immunother. 2016;12(7):1670-7. PubMed PMID: 26901244.

6.Liu X, Da Z, Wang Y, Niu H, Li R, Yu H, He S, Guo M, Wang Y, Luo Y, Ma X, Zhu B*. A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice. Vaccine. 2016;34(11):1370-8. PubMed PMID: 26845736.

7.Luo Y, Ma X, Liu X, Lu X, Niu H, Yu H, Bai C, Peng J, Xian Q, Wang Y, Zhu B*. IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization. Int Immunol. 2016;28(2):77-85.

8.Niu H, Peng J, Bai C, Liu X, Hu L, Luo Y, Wang B, Zhang Y, Chen J, Yu H, Xian Q, Zhu B*. Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice. PLoS One. 2015 Jun 22;10(6):e0130641.

9.Liu X, Wang D, Liu H, Feng Y, Zhu T, Zhang L, Zhu B*, Zhang Y*. Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance. Cell Cycle. 2014;13(11):1702-7.

10.Xin Q, Niu H, Li Z, Zhang G, Hu L, Wang B, Li J, Yu H, Liu W, Wang Y, Da Z, Li R, Xian Q, Wang Y, Zhang Y, Jing T, Ma X, Zhu B*. Subunit vaccine consisting of multi-stage antigens has high protective efficacy against Mycobacterium tuberculosis infection in mice. PLoS One. 2013 Aug 15;8(8):e72745.