方向一：胶质淋巴系统在神经退行性疾病中的调节机制研究，重点阐明AQP4极化、CSF-ISF交换及脑膜淋巴引流等驱动因素如何影响Aβ、tau等病理蛋白清除。通过动物模型和干预实验解析胶质淋巴功能下降对对神经退行性疾病发生发展的影响。

方向二：阿尔茨海默病发病机制及影响因素研究，聚焦Aβ/tau病理发生与传播、神经炎症、胶质细胞及血脑屏障调控。结合血管代谢、生活方式等可干预因素，构建早期预警和干预转化路径。

代表性论文：

1. Hai-Chao Chen; Fu-Lin Gao; Jia-Xin Cao; Yi-Shu Zhang; Lei Wang; Yu-Hong Jing. Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. Clinical & Experimental Ophthalmology. 2026; 0:1–17.

2. Hai Chao Chen; Jia-Xin Cao; Yi-Shu Zhang; Xiao-Mei Su; Yi-Ting Kang; Li-Ping Gao; Yu-Hong Jing. Enriched environment alleviate AD pathological progression by reducing microglia complement signalling in aged male APP/PS1 mice. THE FASEB JOURNAL. 2025. 15;39(17):e71026.

3. Hai Chao Chen; Jia-Xin Cao; Yi-Shu Zhang; Yue-Zhang Ma; Lu Zhang; Xiao-Mei Su; Li-Ping Gao; Yu-Hong Jing. High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP/PS1 mice and induces AD like changes in wild-type mice. Journal of Nutritional Biochemistry. 2024, 125:109570.

4. Hai-Chao Chen, Jia-Xin Cao, Yi-Ting Gai, Hong-Li Du, Xiao-Xia Xi, Jing Sun, Jie Yin, Li-Ping Gao, Yu-Hong Jing. Interaction of human IAPP and Aβ1-42 aggravated the AD-related pathology and impaired the cognition in mice. Experimental Neurology, 2020, 334:113490.

5. Hai-Chao Chen, Yue-Zhang Ma, Jia-Xin Cao, Yi-Shu Zhang, Lu Zhang, Li-Ping Gao, Yu-Hong Jing. Synergistic effects of hIAPP and Aβ1-42 impaired the olfactory function associated with the decline of adult neurogenesis in SVZ. Neuropeptides, 2022, 96:102268-102268.

6. Min-Hua Yao†, Hai-Chao Chen†, Xiao-Yu Zhang, Si-Wei Zhou, Chuan-Xiong Li, Yan-Yu Lu, Zi-Rui Liao, Lei Wang, Ruo-Hui Zhang and Yu-Hong Jing*. Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling. The Journal of Headache and Pain. 2026, (2026) 27:202.

7. Sun Pan-pan1; Chen Hai-Chao1; Guo Wen-ting; Zhang Ze-fan; Sun Shi-hao; Gao Ning-shuang; Jing Yu-Hong; Wang Bao-dui. A ratiometric fluorescent probe revealing the abnormality of acetylated tau by visualizing polarity in Alzheimer's disease. JOURNAL OF MATERIALS CHEMISTRY B. 2024, 12(23):5619-5627.

8. Sun Pan-pan1; Chen Hai-Chao1, Lu Si-yu, Hai Jun, Guo Wen-ting, Jing Yu-Hong, Wang Bao-dui. Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer's Disease: toward Understanding Why H2S Regulates Glutamate-Induced ATP Dysregulation. Analytical Chemistry, 2022, 94(33):11573-11581

9. Gao Li-Ping1, Chen Hai-Chao1, Ma Ze-lin, Chen An-Di, Du Hong-Li, Yin Jie, Jing Yu-Hong. Fibrillation of human islet amyloid polypeptide and its toxicity to pancreatic β-cells under lipid environment. Biochimica Et Biophysica Acta - General Subjects, 2020, 1864(1): 129422-129422

主持项目：

1. 国家自然科学基金，青年科学基金（C类）（82602609），星形胶质细胞α1-AR—CaM信号通路调控AQP4极化促进胶质淋巴循环的机制研究，2027.01-至今，主持。

2. 甘肃省科学技术厅，青年科技基金项目（25JRRA691），Aβ通过星形胶质细胞调节脑膜淋巴循环对阿尔茨海默病病理的影响及其机制，2025.02-至今，主持。
3. 中国博士后科学基金会，第75批面上资助项目（2024M751266），周细胞调节AQP4极化分布促进脑膜淋巴管引流减少Aβ沉积作用及机制，2024.07-2025.12，主持。