神经退行性疾病发病机制与干预策略

以帕金森病为重点，研究蛋白质错误折叠与聚集、神经炎症、“脑-肠”轴等病理机制，发掘早期诊断与靶向治疗候选靶标。

科研成果：

[1] Yongtao He, Jie Gao, Yongpeng Liu, Shuyuan Wu, Junzhe Kuang, Dan Chen, Biao Xu, Mengna Zhang, Quan Fang. Intrathecal semaglutide attenuates burn injury-induced pain in mice through a spinal GLP-1R-linked enkephalin/δ-opioid receptor pathway. Neuropharmacology. 2026 Dec 15:301:111163.

[2] Chao Zhong #, Yongtao He #, Jing Zou, Luyang Gao, Jiahui Wang, Jingyi Zhu, Wenjing Xue, Sanhu Gou, Yun Zhang, Hui Liu, Jingman Ni. A broad-spectrum antimicrobial peptide alleviating antimicrobial resistance and exhibiting potential therapy for bacterial pneumonia. Nature Communications. 2025 Nov 25;16(1):10488. (#Equal contribution).

[3] Yongtao He, Biao Xu, Mengna Zhang, Dan Chen, Shuyuan Wu, Jie Gao, Yongpeng Liu, Zixin Zhang, Junzhe Kuang, Quan Fang. Advances in GLP-1 receptor agonists for pain treatment and their future potential. Journal of Headache and Pain. 2025 Feb 27;26(1):46.

[4] Yongtao He #, Jiayin Zhao #, Yuanyuan Ma #, Xin Yan, Yufei Duan, Xiaoshuang Zhang, Hongtian Dong, Rong Fang, Yunhe Zhang, Qing Li, Ping Yang, Mei Yu, Jian Fei, Fang Huang. Citrobacter rodentium infection-induced gut dysfunction impairs dopamine metabolism and aggravates the pathology of Parkinson’s disease in mice. Journal of Neuroinflammation. 2024 Jun 7;21(1):153. (#Equal contribution).

[5] Yongtao He #, Jiayin Zhao #, Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Huang. TLR2 deficiency is beneficial at the late phase in MPTP-induced Parkinson’s disease. Life Sciences. 2023 Nov 15:333:122171. (#Equal contribution).

[6] Yongtao He, Xinglian Duan, Zhen Guo, Huling Li, Zhanwei Suo, Xian Yang, Mengyuan Zhang, Xiaodong Hu. A synthetic peptide disturbing GluN2A/SHP1 interaction in dorsal root ganglion attenuated pathological pain. European journal of pharmacology. 2019 Jul 5;854:62-69.

[7] Jiayin Zhao #, Yongtao He #, Yufei Duan, Yuanyuan Ma, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Mei Yu, Fang Huang. HDAC6 deficiency has moderate effects on behaviors and Parkinson’s disease pathology in mice. International Journal of Molecular Sciences. 2023, 24(12), 9975. (#Equal contribution).

[8] Jiangping Liu #, Yongtao He #, Xinglian Duan, Zhanwei Suo, Xian Yang, Xiaodong Hu. Enhanced Activities of δ Subunit-containing GABAA Receptors Blocked Spinal Long-term Potentiation and Attenuated Formalin-induced Spontaneous Pain. Neuroscience. 2018 Feb 10;371:155-165. (#Equal contribution).

[9] Shuyuan Wu, Yongtao He, Jiamin Feng, Ning Li, Mengna Zhang, Biao Xu, Nan Zhang, Quan Fang. Advances in the Development and Imaging Applications of Fluorescent Probes for Opioid Receptors. Journal of Medicinal Chemistry. 2026 Oct 8;69(19):21697-21717.

[10] Fangzheng Chen, Yufei Duan, Mengze Wang, Zhaolin Liu, Jiayin Zhao, Guangchun Fan, Yongtao He, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Xin Yan, Chenye Shen, Xiwen Tang, Yuanyuan Ma, Mei Yu, Renyuan Zhou, Jian Fei, Fang Huang. Sex-dependent impact of Il6 deficiency in Parkinson's disease mice. Genes & Diseases. 2025 Dec 15;13(4):101986.

[11] Run Zhang, Nan Zhang, Dan Chen, Xuanran Hu, Mengna Zhang, Minhua Yao, Qinqin Zhang, Shuyuan Wu, Xiaodi Zhang, Yongtao He, Feiyun Gao, Biao Xu, Quan Fang. Neurone-satellite glial cell interactions in dorsal root ganglia drive peripheral sensitisation in a mouse burn pain model. British Journal of Anaesthesia. 2025 Aug;135(2):416-425.

[12] Dan Chen, Mengna Zhang, Yongtao He, Shuyuan Wu, Junzhe Kuang, Zixin Zhang, Biao Xu, Quan Fang. The dual modulating effects of neuropeptide FF on morphine-induced analgesia at the spinal level. Neuroscience. 2025 Jan 26:565:247-256.

[13] Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei, Fang Huang. Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease. Journal of Neuroinflammation. 2024 Mar 30;21(1):80.

[14] Xiaoshuang Zhang, Yunhe Zhang, Boya Wang, Chuantong Xie, Jinghui Wang, Rong Fang, Hongtian Dong, Guangchun Fan, Mengze Wang, Yongtao He, Chenye Shen, Yufei Duan, Jiayin Zhao, Zhaolin Liu, Qing Li, Yuanyuan Ma, Mei Yu, Jian Wang, Jian Fei, Lei Xiao, Fang Huang. Pyroptosis-mediator GSDMD promotes Parkinson's disease pathology via microglial activation and dopaminergic neuronal death. Brain, Behavior, and Immunity. 2024 Jul:119:129-145.

[15] Xiaochen Bai, Jinghui Wang, Xiaoshuang Zhang, Yilin Tang, Yongtao He, Jiayin Zhao, Linlin Han, Rong Fang, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Yuanyuan Ma, Mei Yu, Ruilin Sun, Jian Wang, Jian Fei, Fang Huang. Deficiency of miR-29a/b1 leads to premature aging and dopaminergic neuroprotection in mice. Frontiers in Molecular Neuroscience. 2022 Oct 6:15:978191.

[16] Chao Zhong, Tianqi Liu, Sanhu Gou, Yongtao He, Ningyi Zhu, Yuewen Zhu, Li Wang, Hui Liu, Yun Zhang, Jia Yao, Jingman Ni. Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. European Journal of Medicinal Chemistry. 2019 Nov 15;182:111636.

[17] Ziyang Zhang, Zhen Guo, Huling Li, Yongtao He, Xinglian Duan, Zhanwei Suo, Xian Yang, Xiaodong Hu. Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn. Neuropharmacology. 2019 Apr;148:358-365.

[18] Xinglian Duan, Zhen Guo, Yongtao He, Yinxia Li, Yanni Liu, Huhu Bai, Huling Li, Xiaodong Hu, Zhan-Wei Suo. SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain. Neuroscience. 2020 Mar 1;429:203-212.

[19] Jiyuan Zhao, Xinglian Duan, Li Yang, Jiangping Liu, Yongtao He, Zhen Guo, Xiaodong Hu, Zhan-Wei Suo. Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain. Neuroscience. 2018 Sep 15;388:1-10.

[专利]一种建立帕金森病动物模型的方法. 黄芳, 何永涛, 余梅, 李青, 赵佳音. CN115777625B.

主持及参与的科研项目：

[1] 甘肃省自然科学基金项目（26JRRA209），2026.2-2029.2，在研；

[2] 国家自然科学基金面上项目：IL33/ST2通路在帕金森病中的作用与机制研究(No.32271003). 202301-202612, 参与；

[3] 国家自然科学基金面上项目：NOD样受体NLRC5在帕金森病中的作用与机制研究 (No.31970908). 202001-202312, 参与；

[4] 国家自然科学基金面上项目：脊髓背角“mGluR5/ERK信号通路”对甘氨酸受体的α1L亚基的特异性抑制作用 (No.31771160). 201801-202112, 参与；

[5] 国家自然科学基金面上项目：酪氨酸磷酸酶PTP1B恶化脊髓 NMDA受体痛觉传递的分子机制 (No.31471060). 201501-201812, 参与；