哺乳动物早期胚胎发育、干细胞表观命运编辑、配子体外分化及线粒体在其中的作用

主持科研项目

1.2024年瑞典Karolinska institutet医学院的年轻科学家特别资助基金，主持，结项

2.2022年瑞典Karolinska institutet医学院Birgitta and Carl-Axel Rydbeck儿科研究基金，主持，结项

3.2019年国自然青年项目基金(31801206)，主持，结项

4.2018年中国博士后面上项目基金(2018M640420)，主持，结项

5.2018年上海市“超级博士后”项目(2018056)，主持，结项

6.2017年国自然基金重点项目 (81630035)，参与，结项

代表性论文：

以下列表中 # 表示为共同一作

[1]. Wenteng He#, Qing Luo#, Jian Zhao, Mengting Wang, Allan Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan-Bernd Stukenborg, Jiayu Chen, Qiaolin Deng. (2025). " X-linked gene dosage and SOX2 act as key roadblocks for human germ cell specification in Klinefelter syndrome." Advanced Science.

[2]. Wenteng He#, Hongming Tang#, Yuanyuan Li, Mingzhu Wang, Yuanyuan Li, Jiayu Chen, Shaorong Gao, Zhiming Han. (2024). "Overexpression of let-7a mitigates diploidization in mouse androgenetic haploid embryonic stem cells." iScience. 27(5): 109769.

[3]. Allan Zhao, Hong Jiang, Arturo Reyes Palomares, Alice Larsson, Wenteng He, Jacob Grünler, Xiaowei Zheng, Kenny Rodriguez-Wallberg, Sergiu-Bogdan Catrina, and Qiaolin Deng. (2024). "Appropriate glycemic management protects the germline but not uterine environment in hyperglycemia." EMBO Reports. 25(4): 1752-1772

[4]. Weisheng Zheng#, Liping Wang#, Wenteng He, Xinjie Hu, Qianshu Zhu, Liang Gu, Cizhong Jiang. (2023). "Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells." Cell Proliferation: e13436.

[5]. Wenteng He#, Jiayu Chen#, Shaorong Gao. (2019). "Mammalian haploid stem cells: establishment, engineering and applications." Cellular and Molecular Life Sciences 76(12): 2349-2367.

[6]. Yingdong Liu#, Yanping Zhang#, Jiqing Yin, Yawei Gao, Yanhe Li, Dandan Bai, Wenteng He, Xueliang Li, Pengfei Zhang, Rongnan Li, Lingkai Zhang, Yanping Jia, Yalin Zhang, Jiaming Lin, Yi Zheng, Hong Wang, Shaorong Gao, Wenxian Zeng, Wenqiang Liu. (2019). "Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis." Journal of Biological Chemistry 294(49): 18714-18725.

[7]. Wenteng He#, Xiaobai Zhang#, Yalin Zhang, Weisheng Zheng, Zeyu Xiong, Xinjie Hu,Mingzhu Wang, Linfeng Zhang, Kun Zhao, Zhibin Qiao, Weiyi Lai, Cong Lv, Xiaochen Kou,Yanhong Zhao, Jiqing Yin, Wenqiang Liu, Yonghua Jiang, Mo Chen, Ruimin Xu, Rongrong Le,Chong Li, HongWang, XiaopingWan, HailinWang, Zhiming Han, Cizhong Jiang,* Shaorong Gao,*and Jiayu Chen*. (2018). "Reduced self-diploidization and improved survival of semi-cloned mice produced from androgenetic haploid embryonic stem cells through overexpression of Dnmt3b." Stem Cell Reports 10(2): 477-493.

[8]. Zeyu Xiong, Li Yi, Dingya Cao, Wenteng He, Jiayu Chen, Shaorong Gao, Xiaofang Sun (2016). "Dravet syndrome with autism inherited from a paternal mosaic heterozygous mutation on SCN1A." Journal of the Neurological Sciences 369: 53-56.

[9]. Bingjie Zhang#, Hui Zheng#, Bo Huang#, Wenzhi Li#,Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na&Wei Xie. (2016). "Allelic reprogramming of the histone modification H3K4me3 in early mammalian development." Nature 537(7621): 553-557.

[10]. Qi Chen, Shuai Gao, Wenteng He, Xiaochen Kou, Yanhon Zhao, Hong Wang, Shaorong Gao (2014). "Xist repression shows time-dependent effects on the reprogramming of female somatic cells to iPSCs." Stem Cells Oct;32(10):2642-56.

[11]. Wenqiang Liu, Jiqing Yin, Xiaochen Kou, Yonghua Jiang, Haibo Gao, Yanhong Zhao, Bo Huang, Wenteng He, Hong Wang, Zhiming Han, Shaorong Gao.(2014)."Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes." Cell reports 6(6): 1008-1016.

[12]. Gerelchimeg Bou, Mingju Sun, Ming Lv, Jiang Zhu, Hui Li, Juan Wang, Lu Li, Zhongfeng Liu, Zhong Zheng, Wenteng He, Qingran Kong, Zhonghua Liu (2014). "A pre-breeding screening program for transgenic boars based on fluorescence in situ hybridization assay." Transgenic Research: 1-11.

[13]. Wenteng He#, Qingran Kong#, Yongqian Shi, Bingteng Xie, Mingxia Jiao, Tianqing Huang, Shimeng Guo, Kui Hu, Zhonghua Liu (2013). "Generation and Developmental Characteristics of Porcine Tetraploid Embryos and Tetraploid/diploid Chimeric Embryos." Genomics, Proteomics & Bioinformatics 11(5): 327-333.

[14]. 熊泽宇#, 何文腾#, 陈嘉瑜, 韩之明,孙筱放,高绍荣.小鼠孤雄单倍体胚胎干细胞增殖的研究. 中国细胞生物学学报,2016, 38(8): 926-934

[15]. 吕明#, 何文腾#，焦明霞，郇延军，石永乾，孔庆然，刘忠华. 甲基-β-环化糊精对猪体外受精及早期胚胎发育的影响. 畜牧与兽医.2012. 44(012): 25-29.

[16]. 陈墨, 寇晓晨，何文腾，刘忠华. Xist敲降可以改善孤雄单倍体囊胚质量. 动物学杂志 2017.52(05): 835-841.

[17]. 周华龙,孙铭菊，刘世超，郭佳，何文腾，胡魁，尹智，刘忠华，崔卫国，格日乐其木格. (2015). "顶体反应进程对公猪精液体外受精最佳精卵比的影响." 畜牧与兽医(12): 17-24.

[18]. 石永乾, 何文腾，周洋，焦明霞，谢炳腾，胡魁，孔庆然，刘忠华. (2012). "慢病毒载体介导的绿色荧光蛋白转基因标记法研究猪嵌合体制作." 中国生物工程杂志 32(008): 68-74.

[19]. 张鑫淼, 韩小娇，何文腾，刘世超，牟彦双，胡魁，刘忠华. (2012). "猪 sall4b 基因的克隆及表达分析." 生物工程学报 28(010): 1164-1174.

[20]. 刘彪, 逯心玉，孔庆然，苏兴盼，何文腾，胡魁，刘忠华. (2012). "精浆对猪精子冷冻效果影响的研究." 中国畜牧兽医 39(11): 161-164.

[21]. 刘忠华, 韩小娇，张鑫淼，王娟，牟彦双，何文腾，黄天晴，孔庆然，姜丹丹，丛义梅，尹智. (2012). "猪源 Lin28 基因的克隆及其在猪胎儿成纤维细胞中的表达." 东北农业大学学报 43(9): 26-31.   

[22]. 黄波, 郇延军，石永乾，王峰，何文腾，张鑫淼，刘仲凤，朱江，吕明，刘忠华. (2011). "TSA 浓度及处理时间对猪体细胞核移植胚胎体外发育影响." 东北农业大学学报 42(3): 122-126.

专利：

1. 2013年10月16日 一种转基因种公猪选择方法及其应用技术(CN103352072A)   发明型   排名第4

2. 2013年 8月14日 一种简易快速的猪囊胚差异染色方法技术(CN103245546A)   发明型   排名第3