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张伟

【来源:基础医学院 | 发布日期:2013-10-18 | 作者:基础医学院 】     【选择字号:

张伟,博士,讲师。2011年于兰州大学生命科学院获得博士学位。2011-2013年在兰州大学第一临床医学院从事博士后研究。
 
科研方向:
1.  抗菌肽药物的设计及多功能研究                                      
       发展多类高效低毒的抗菌肽药物,用于肿瘤、细菌感染以及炎症的治疗。
2.  多肽载体的设计及应用                                       
       基于穿膜肽发展高效低毒的载体,用于基因和抗肿瘤药物的的靶向运输。
 
荣誉称号及奖励:
1.  2013年,中国药学会科学技术奖一等奖(第五完成人)
                                                                                                        
主持的科研项目:
1.  主持中国博士后科学基金特别资助一项(2013T60896),双功能抗菌肽的设计及抗菌活性研究, 2013.5-2014.12
 
2.  主持中国博士后科学基金面上资助一项(2012M512047),新型酸激活基因载体的设计及应用,2012.5-2013.12
 
参与科研项目情况:
1.         以项目组主要成员(2/9)参与国家自然科学基金委——面上项目一项(81273440),高稳定性酸敏感穿膜肽的设计与应用,2013.1-2016.12
2.         以项目组主要成员(2/8)参与国家自然科学基金委——青年科学基金项目一项(81202400),具有重要医药用途的神经肽的化学修饰及作用机制研究,2013.1-2015.12
 
发表论文:
1.         Zhang Wei, Song JJ, Liang RR, Zheng X, Chen JB, Li GL, Zhang BZ, Yan X, Wang R*. Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. Bioconjugate Chem, 2013. (accepted) (SCI二区,影响因子4.58)
2.         张伟, 宋竟婧, 张邦治, 杨雯乐, 王 锐*. 多肽新药研发策略的研究进展. 中国科学:化学, 2013, 43, 939-940.
3.         Zhang Wei, Song JJ, Liang RR, Zheng X, Chen JB, Li GL, Zhang BZ, Wang KR, Yan X, Wang R*. Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer. Peptides, 2013, 46C:33-39. (SCI三区,影响因子2.522)
4.         Zhang Wei, Song Jingjing, Zhang BZ, Liu LW, Wang KR, Wang R*. Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chem, 2011, 22:1410-1415. (SCI二区,影响因子4.58)
5.         Zhang Wei, Song JJ, Mu LY, Zhang BZ, Liu LW, Xing YH, Wang KR, Li ZY, Wang R*. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorg Med Chem Lett, 2011, 21:1452-1455. (SCI三区,影响因子2.338)
6.         Zhang Wei, Li J, Liu LW, Wang KR, Song Jingjing, Yan JX, Li ZY, Zhang BZ, Wang R*. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31:1832-1838. (SCI三区,影响因子2.522)
7.         Song J, Zhang Wei, Kai M, Chen J, Liang R, Zheng X, Li G, Zhang B, Wang K, Zhang Y, Yang Z, Ni J, Wang R. Design of an Acid-Activated Antimicrobial Peptide for Tumor Therapy. Mol Pharm. 2013,10: 2934-2941 (共同第一作者) (SCI二区,影响因子4.57)
8.         Xing Y, Zhang Wei, Song J, Zhang Y, Jiang X, Wang R. Anticancer effects of a novel class rosin-derivatives with different mechanisms. Bioorg Med Chem Lett. 2013, 23:3868-72. (共同第一作者) (SCI三区,影响因子2.338)
9.         Liu J, Zhang Wei, Zhang H, Yang Z, Li T, Wang B, Huo X, Wang R, Chen H. A multifunctional nanoprobe based on Au-Fe3O4 nanoparticles for multimodal and ultrasensitive detection of cancer cells. Chem Commun (Camb). 2013, 49:4938-40. (SCI二区,影响因子6.378)
10.     Zhi LH, Liu J, Wang Y, Zhang Wei, Wang BD *, Xu ZG, Yang ZY, Huo X, Li GM. Multifunctional Fe3O4 nanoparticles for highly sensitive detection and removel of Al(III) in aqueous solution. Nanoscale, 2013, 5:1552-1556. (SCI一区,影响因子6.233)
11.     Wang K, Yan J, Dang W, Liu X, Chen R, Zhang J, Zhang B, Zhang Wei, Kai M, Yan W, Yang Z, Xie J, Wang R*. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides, 2013, 39:80-8. (SCI三区,影响因子2.522)
12.     Wang KR, Yan JX, Chen R, Dang W, Zhang BZ, Zhang Wei, Song JJ, Wang R*. Membrane-active action mode of Polybia-CP, a novel antimicrobial peptide isolated from the venom of Polybia Paulista. Antimicrob Agents Chemother, 2012, 56:3318-3323. (SCI二区,影响因子4.565)
13.     Yan JX, Wang KR, Chen R, Song JJ, Zhang BZ, Dang W, Zhang Wei, Wang R*. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie, 2012, 94:184-191. (SCI三区,影响因子3.142)
14.     Song Jingjing, Kai M, Zhang Wei, Zhang JD, Liu LW, Zhang BZ, Liu X, Wang R*. Cellular uptake of transportan 10 and its analogs in live cells: Selectivity and structure–activity relationship studies. Peptides, 2011, 32:1934-1941. (SCI三区,影响因子2.522)
15.     Wang KR, Yan JX, Liu X, Zhang JD, Chen R, Zhang BZ, Dang W, Zhang Wei, Kai M, Song Jingjing, Wang R*. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista. Toxicology, 2011, 288:27-33. (SCI二区,影响因子4.017)
16.     Zhang BZ, Wang KR, Yan JX, Zhang Wei, Song Jingjing, Ni JM, Wang R*. In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010, 31:568-573. (SCI三区,影响因子2.522)
17.     Wang KR, Zhang BZ, Zhang Wei, Yan JX, Li XL, Wang R*. Potent antitumor effects of a novel actinomycin D analog Leu5AMD. Cancer Lett, 2008, 268:38-45. (SCI二区,影响因子4.258)
18.     Wang KR, Zhang BZ, Zhang Wei, Yan JX, Li J, Wang R*. Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides, 2008, 29:963-938. (SCI三区,影响因子2.522)
 
专利
[1]      王锐,宋竟婧,张伟,开明,张邦治;“具有酸激活特性的抗菌肽AMitP及其合成和在制备抗肿瘤药物中的应用”,2012,中国,申请号:201210221080.4
[2]      王锐,张伟,宋竟婧,张邦治;“基于N末端18烷酰化抗菌肽构建的非病毒基因载体”,2012,中国, 申请号:201210221082.3 申请日期:2012.06.29
 
学院地址: 甘肃省兰州市东岗西路199号 兰州大学基础医学院 邮编: 730000
电 话: 0931-8915023 8915092 传真: 0931-8915023 电子邮箱: jcyxy@lzu.edu.cn