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王凯荣

【来源:基础医学院 | 发布日期:2013-03-14 | 作者:基础医学院 】     【选择字号:
王凯荣,男,博士,副教授,硕士生导师。 2009 年于兰州大学获得理学博士学位,同年留校在医学生物化学与分子生物学研究所从事教学科研工作,主要从事多肽药物分子设计、合成及抗菌肽抗肿瘤、抗菌、抗真菌活性、作用机制及构效关系研究,相关研究工作已发表SCI研究论文35篇;目前申请人已经主持完成国家自然科学基金青年基金项目一项,教育部博士点新教师基金项目一项,教育部“春晖计划”合作项目一项;作为项目组成员参与完成 “国家科技重大专项”项目2009ZX09503-017和2012ZX09504001-003的完成;参与完成国家自然科学基金重大研究计划一项(91413107);当前主持在研国家自然科学基金面上项目一项。2012年获第十二届中国国际多肽学术会议青年论文奖(Young Peptide Scienctist Award); 2013年10月获第十二届张锡均基金会全国青年优秀生理学学术论文优秀口头报告奖(中国生理学会)。
   
  
 
 
   
   
 教育、研究工作经历:
    2000.9-2004.7 西北师范大学生命科学学院,获得学士学位。
    2004.9-2009.7 兰州大学生命科学学院,生物化学与分子生物学专业,获得博士学位。
    2009.7—2012.5  兰州大学,基础医学院/甘肃省新药临床前研究重点实验室,讲师;
    2012.5—   兰州大学,基础医学院/甘肃省新药临床前研究重点实验室,副教授,硕士生导师。
2015.12-2016.12  Erasmus University, Medical Center, 访问学者,合作导师:Luc van der Laan
主持项目:
1.教育部“春晖计划”合作科研项目“抗菌肽优化设计合成、构效关系及膜-肽作用分子动力学机制研究”(No.Z2010082), 2011.7—2013.7;已结题;
2.教育部博士点新教师基金项目“抗菌肽polybia-MPI 的新型类似物的设计合成、抗菌活性及构效关系研究”(No.20120211120045), 2013.1-2015.12;已结题;
3.国家自然科学基金青年基金项目“以细胞膜为靶标的新型抗菌肽polybia-MPI类似物的设计、合成及抗菌活性研究”(No.31200584), 2013.01-2015.12;已结题;
4.兰州大学中央高校自由探索面上项目“新型抗菌肽氟代衍生物抗真菌活性、作用机制及构效关系研究”(No.lzujbky-2013-164),2013.1-2014.6;已结题;
5. 国家自然科学基金面上项“化学修饰策略构建高稳定性抗菌肽polybia-CP衍生物及其抗真菌活性研究”(No. 81573265), 2016/01-2017/12;在研;
6. 教育部“春晖计划”合作科研项目“赖氨酸侧链修饰的抗菌肽protonectin衍生物的稳定性、抗菌活性及作用机制研究”,(Z2016002),2016.12-2018.12;在研;
已发表论文目录(第一作者和通讯作者,IF2016年最新发布):
1. Q Shuai, R Zhu, Y Zhao, X An, F Jia, J Peng, Z Ma, Y Zhu, J Wang, J Su, Q Wang, H Wan, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of protonectin with D-amino acid substitutions, J Pept Sci., 2017;DOI: 10.1002/psc.2989. (SCI, IF=1.951)
2. Z Dong, Y Zhu, B Li, C Wang,  Wenjin Yan*, Kairong Wang*, Rui Wang*, Asymmetric Synthesis of #-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction. J Org Chem., 2017; DOI: 10.1021/acs.joc.6b02949. (SCI二区, IF=4.785)
3. Y Zhao, M Zhang, S Qiu, J Wang, J Peng, P Zhao, R Zhu, H Wang, Y Li, Kairong Wang*, Wenjin Yan*, Rui Wang*, Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI. AMB Express, 2016; 6(1):122. (SCI二区, IF=2.167) 
4. J Su, Z Ma, X Li, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang*,Asymmetric Synthesis of 2′-Trifluoromethylated Spiro-pyrrolidine-3,3′-oxindoles viaSquaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition. Advanced Synthesis & Catalysis, 2016;358:3777-3785. (SCI一区, IF-=6.453)
5. Y Zhu, Z Dong,X Cheng, X Zhong, X Liu, L Lin, Z Shen, P Yang, Y Li, H Wang, Wenjin Yan*, Kairong Wang*, Rui Wang. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction. Organic Lett, 2016;18(15):3546-3549. (SCI一区, IF= 6.732)
6. X Li, J Su, Z Liu, Y Zhu, Z Dong, S Qiu, J Wang, L Lin, Z Shen, Wenjin Yan*, Kairong Wang*, Rui Wang*, Synthesis of Chiral α-Trifluoromethylamines with 2, 2,2-Trifluoroethylamine asa ‘Building Block’. Organic Lett., 2016;18(5):956-959. ((SCI一区, IF= 6.732)
7. Kairong Wang, F Jia , W Dang, Y Zhao, R Zhu, M Sun, S Qiu, X An, Z Ma, Y Zhu, J Yan, Z Kong, Wenjin Yan* , Rui Wang*. Antifungal effect and action mechanism of antimicrobial peptide polybia-CP.  J Pept Sci., 2016;22(1):28-35. (SCI, IF=1.951)
8. Y Zhu, X Li, Q Chen, J Su, F Jia, S Qiu, M Ma, Q Sun, Wenjin Yan*, Kairong Wang*, Rui Wang*, Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-containing Chromanes. Organic Lett., 2015;17(15): 3826-3829. (SCI一区, IF= 6.732)
9. Q Sun, X Li, J Su, L Zhao, M Ma, Y Zhu, Y Zhao, R Zhu, Wenjin Yan*, Kairong Wang*, Rui Wang. The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5'-Trifluoromethyl-spiro[pyrrolidin-3,2'-oxindoles]. Advanced Synthesis & Catalysis, 2015;357(14-15):3187-3196. (SCI一区, IF-=6.453)
10. M Ma, Y Zhu, Q Sun, X Li, J Su, L Zhao, Y Zhao, S Qiu, Wenjin Yan*, Kairong Wang*, Rui Wang*. The Asymmetric Synthesis of CF3- containing Spiro[pyrrolidin-3,2’-oxindole] through the Organocatalytic 1, 3-dipolar Cycloaddition Reaction. Chem. Comm.2015;51(42):8789-8792. (SCI一区, IF= 6.567)
11. Kairong Wang, W Dang, J Xie, R Zhu, M Sun, F Jia, Y Zhao, X An, S Qiu, X Li, Z Ma, Wenjin Yan*, Rui Wang*. Antimicrobial peptide protonectin disturbs the membrane integrity andinduces ROS production in yeast cells,Biochimica et Biophysica Acta-Biomembranes. 2015;1848(10):2365-2373. (SCI二区, IF=3.687)
12. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 56:22-29. (SCI, IF=2.525)
13. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrob. Agents Chemother., 2013,57(10), 4632–9. (SCI二区, IF=4.415, Top期刊)
14. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88. (SCI,IF=2.525)
15. J Yan1, Kairong Wang1, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (并列第一作者,SCI二区,IF=4.415, Top 期刊)
16. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. (SCI二区, IF=4.415, Top 期刊)
17. J Yan1, Kairong Wang1, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie  2012,94 184-191. (SCI, 并列第一作者,IF =3.017).
18. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33. (SCI二区, IF =3.847)
19. B Zhang1, Kai-rong Wang1, W Zhang, J Yan, J Song, Rui Wang . In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573. (SCI,并列第一作者, IF =2.525)
20. Kairong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett., 2009, 278,65-72.(SCI二区, IF =5.992)
21. Kairong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett., 2008,268,38-45. (SCI二区, IF =5.992)
22. Kairong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8. (SCI, IF 2.525).
学院地址: 甘肃省兰州市东岗西路199号 兰州大学基础医学院 邮编: 730000
电 话: 0931-8915023 8915092 传真: 0931-8915023 电子邮箱: jcyxy@lzu.edu.cn